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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Relationship between exposure, clinical malaria, and age in an area of changing transmission intensity
American Journal of Tropical Medicine and Hygiene, Volume 79, No. 2, Year 2008
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Description
The relationship between malaria transmission intensity and clinical disease is important for predicting the outcome of control measures that reduce transmission. Comparisons of hospital data between areas of differing transmission intensity suggest that the mean age of hospitalized clinical malaria is higher under relatively lower transmission, but the total number of episodes is similar until transmission drops below a threshold, where the risks of hospitalized malaria decline. These observations have rarely been examined longitudinally in a single community where transmission declines over time. We reconstructed 16 years (1991-2006) of pediatric hospital surveillance data and infection prevalence surveys from a circumscribed geographic area on the Kenyan coast. The incidence of clinical malaria remained high, despite sustained reductions in exposure to infection. However, the age group experiencing the clinical attacks of malaria increased steadily as exposure declined and may precede changes in the number of episodes in an area with declining transmission. Copyright © 2008 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
O'Meara, Wendy Prudhomme
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Mwangi, Tabitha Wanja
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Williams, Thomas Neil
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
McKenzie, F. Ellis
Unknown Affiliation
Snow, Robert William
United Kingdom, Oxford
University of Oxford
Marsh, Kevin
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
Statistics
Citations: 108
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.4269/ajtmh.2008.79.185
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study