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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Great ape genetic diversity and population history
Nature, Volume 499, No. 7459, Year 2013
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Description
Most great ape genetic variation remains uncharacterized; however, its study is critical for understanding population history, recombination, selection and susceptibility to disease. Here we sequence to high coverage a total of 79 wild- and captive-born individuals representing all six great ape species and seven subspecies and report 88.8 million single nucleotide polymorphisms. Our analysis provides support for genetically distinct populations within each species, signals of gene flow, and the split of common chimpanzees into two distinct groups: Nigeria-Cameroon/western and central/eastern populations. We find extensive inbreeding in almost all wild populations, with eastern gorillas being the most extreme. Inferred effective population sizes have varied radically over time in different lineages and this appears to have a profound effect on the genetic diversity at, or close to, genes in almost all species. We discover and assign 1,982 loss-of-function variants throughout the human and great ape lineages, determining that the rate of gene loss has not been different in the human branch compared to other internal branches in the great ape phylogeny. This comprehensive catalogue of great ape genome diversity provides a framework for understanding evolution and a resource for more effective management of wild and captive great ape populations. © 2013 Macmillan Publishers Limited. All rights reserved.
Authors & Co-Authors
Prado-Martinez, Javier
Unknown Affiliation
Sudmant, Peter H.
Unknown Affiliation
Kidd, Jeffrey M.
Unknown Affiliation
Li, Heng
Unknown Affiliation
Kelley, Joanna L.
Unknown Affiliation
Lorente-Galdos, Belen
Unknown Affiliation
Veeramah, Krishna R.
Unknown Affiliation
Woerner, August E.
Unknown Affiliation
O'Connor, Timothy D.
Unknown Affiliation
Santpere, Gabriel
Unknown Affiliation
Cagan, Alex T.J.
Unknown Affiliation
Theunert, Christoph
Unknown Affiliation
Casals, Ferran
Unknown Affiliation
Laayouni, Hafid
Unknown Affiliation
Munch, Kasper
Unknown Affiliation
Hobolth, Asger
Unknown Affiliation
Halager, Anders E.
Unknown Affiliation
Malig, Maika
Unknown Affiliation
Hernandez-Rodriguez, Jessica
Unknown Affiliation
Hernando-Herraez, Irene
Unknown Affiliation
Prüfer, Kay
Unknown Affiliation
Pybus, Marc
Unknown Affiliation
Johnstone, Laurel
Unknown Affiliation
Lachmann, Michael
Unknown Affiliation
Alkan, Can
Unknown Affiliation
Twigg, Dorina
Unknown Affiliation
Petit, Natalia
Unknown Affiliation
Baker, Carl A.
Unknown Affiliation
Hormozdiari, Fereydoun
Unknown Affiliation
Fernandez-Callejo, Marcos
Unknown Affiliation
Dabad, Marc
Unknown Affiliation
Wilson, Michael L.
Unknown Affiliation
Stevison, Laurie
Unknown Affiliation
Camprub, Cristina
Unknown Affiliation
Carvalho, Tiago
Unknown Affiliation
Ruiz-Herrera, Aurora
Unknown Affiliation
Vives, Laura
Unknown Affiliation
Melé, Marta
Unknown Affiliation
Abello, Teresa
Unknown Affiliation
Kondova, Ivanela I.
Unknown Affiliation
Bontrop, Ronald E.
Unknown Affiliation
Pusey, Anne E.
Unknown Affiliation
Lankester, Felix
Unknown Affiliation
Kiyang, John Anyam
Unknown Affiliation
Bergl, Richard A.
Unknown Affiliation
Lonsdorf, Elizabeth V.
Unknown Affiliation
Myers, Simon R.
Unknown Affiliation
Ventura, Mario
Unknown Affiliation
Gagneux, Pascal
Unknown Affiliation
Comas, D.
Unknown Affiliation
Siegismund, Hans Redlef
Unknown Affiliation
Blanc, Julie
Unknown Affiliation
Agueda-Calpena, Lidia
Unknown Affiliation
Gut, Marta
Unknown Affiliation
Fulton, Lucinda L.
Unknown Affiliation
Tishkoff, Sarah A.
Unknown Affiliation
Mullikin, James C.
Unknown Affiliation
Wilson, Richard K.
Unknown Affiliation
Gut, I. Glynne
Unknown Affiliation
Gonder, Mary Katherine
Unknown Affiliation
Ryder, Oliver A.
Unknown Affiliation
Hahn, Beatrice H.
Unknown Affiliation
Navarro, Arcadi
Unknown Affiliation
Akey, Joshua M.
Unknown Affiliation
Bertranpetit, Jaume
Unknown Affiliation
Reich, David E.
Unknown Affiliation
Mailund, Thomas
Unknown Affiliation
Schierup, Mikkel Heide
Unknown Affiliation
Hvilsom, Christina
Unknown Affiliation
Andrés, Aida M.
Unknown Affiliation
Wall, Jeffrey D.
Unknown Affiliation
Bustamante, Carlos Daniel
Unknown Affiliation
Hammer, Michael F.
Unknown Affiliation
Eichler, Evan E.
Unknown Affiliation
Marques-Bonet, Tomas
Unknown Affiliation
Statistics
Citations: 771
Authors: 75
Affiliations: 36
Identifiers
Doi:
10.1038/nature12228
ISSN:
00280836
e-ISSN:
14764687
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study
Study Locations
Cameroon
Nigeria