Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Plasmacytoid dendritic cells infiltrate the skin in positive tuberculin skin test indurations
Journal of Investigative Dermatology, Volume 132, No. 1, Year 2012
Notification
URL copied to clipboard!
Description
Plasmacytoid dendritic cells (pDCs) are rarely present in normal skin but have been shown to infiltrate lesions of infections or autoimmune disorders. Here, we report that several DC subsets including CD123+ BDCA-2/CD303+ pDCs accumulate in the dermis in indurations induced by the tuberculin skin test (TST), used to screen immune sensitization by Mycobacterium tuberculosis. Although the purified protein derivate (PPD) used in the TST did not itself induce pDC recruitment or IFN-α production, the positive skin reactions showed high expression of the IFN-α-inducible protein MxA. In contrast, the local immune response to PPD was associated with substantial cell death and high expression of the cationic antimicrobial peptide LL37, which together can provide a means for pDC activation and IFN-α production. In vitro, pDCs showed low uptake of PPD compared with CD11c + and BDCA-3/CD141+ myeloid DC subsets. Furthermore, supernatants from pDCs activated with LL37-DNA complexes reduced the high PPD uptake in myeloid DCs, as well as decreased their capacity to activate T-cell proliferation. Infiltrating pDCs in the TST reaction site may thus have a regulatory effect upon the antigen processing and presentation functions of surrounding potent myeloid DC subsets to limit potentially detrimental and excessive immune stimulation. © 2012 The Society for Investigative Dermatology.
Authors & Co-Authors
Bond, Emily
Sweden, Stockholm
Karolinska Universitetssjukhuset
Liang, Frank
Sweden, Stockholm
Karolinska Universitetssjukhuset
Sandgren, Kerrie J.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Smed-Sörensen, Anna
Sweden, Stockholm
Karolinska Institutet
Bergman, P. W.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Brighenti, Susanna Grundström
Sweden, Stockholm
Karolinska Universitetssjukhuset
Adams, William C.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Betemariam, Senait A.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Rangaka, Molebogeng Xheeda
South Africa, Cape Town
University of Cape Town
Lange, Christoph G.
Germany, Borstel
Clin. Infectious Diseases and Center for Clinical Studies Medical Clinic Tuberculosis Center Borstel
Wilkinson, Robert J.
South Africa, Cape Town
University of Cape Town
United Kingdom, London
Mrc National Institute for Medical Research
United Kingdom, London
Imperial College London
Andersson, Jan P.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Loré, Karin
Sweden, Stockholm
Karolinska Universitetssjukhuset
Statistics
Citations: 28
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1038/jid.2011.246
ISSN:
0022202X
e-ISSN:
15231747
Research Areas
Genetics And Genomics