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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Camelid immunoglobulins and nanobody technology
Veterinary Immunology and Immunopathology, Volume 128, No. 1-3, Year 2009
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Description
It is well established that all camelids have unique antibodies circulating in their blood. Unlike antibodies from other species, these special antibodies are devoid of light chains and are composed of a heavy-chain homodimer. These so-called heavy-chain antibodies (HCAbs) are expressed after a V-D-J rearrangement and require dedicated constant γ-genes. An immune response is raised in these so-called heavy-chain antibodies following classical immunization protocols. These HCAbs are easily purified from serum, and the antigen-binding fragment interacts with parts of the target that are less antigenic to conventional antibodies. Since the antigen-binding site of the dromedary HCAb is comprised in one single domain, referred to as variable domain of heavy chain of HCAb (VHH) or nanobody (Nb), we designed a strategy to clone the Nb repertoire of an immunized dromedary and to select the Nbs with specificity for our target antigens. The monoclonal Nbs are well produced in bacteria, are very stable and highly soluble, and bind their cognate antigen with high affinity and specificity. We have successfully developed recombinant Nbs for research purposes, as probe in biosensors, to diagnose infections, and to treat diseases like cancer or trypanosomosis. © 2008 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Muyldermans, Serge
Belgium, Brussels
Vrije Universiteit Brussel
Baral, Toya Nath
Belgium, Brussels
Vrije Universiteit Brussel
Retamozzo, V. Cortez
Belgium, Brussels
Vrije Universiteit Brussel
de Baetseĺier, Patrick C.
Belgium, Brussels
Vrije Universiteit Brussel
De-Genst, Erwin J.
Belgium, Brussels
Vrije Universiteit Brussel
Kinne, Jöerg
United Arab Emirates, Dubai
Central Veterinary Research Laboratory Dubai
Leonhardt, Heinrich
Germany, Munich
Ludwig-maximilians-universität München
Germany, Munich
Munich Center for Integrated Protein Science
Magez, Stefan
Belgium, Brussels
Vrije Universiteit Brussel
Khong, Nguyen Viet
Belgium, Brussels
Vrije Universiteit Brussel
Revets, Hilde
Belgium, Brussels
Vrije Universiteit Brussel
Rothbauer, Ulrich
Germany, Munich
Ludwig-maximilians-universität München
Germany, Munich
Munich Center for Integrated Protein Science
Stijlemans, Benoît
Belgium, Brussels
Vrije Universiteit Brussel
Tillib, S.
Russian Federation, Moscow
Institute of Gene Biology, Russian Academy of Sciences
Wernery, Ullrich
United Arab Emirates, Dubai
Central Veterinary Research Laboratory Dubai
Wyns, Lode
Belgium, Brussels
Vrije Universiteit Brussel
Hassanzadeh-Ghassabeh, Gh
Belgium, Brussels
Vrije Universiteit Brussel
Saerens, Dirk
Belgium, Brussels
Vrije Universiteit Brussel
Statistics
Citations: 461
Authors: 17
Affiliations: 5
Identifiers
Doi:
10.1016/j.vetimm.2008.10.299
ISSN:
01652427
Research Areas
Cancer
Maternal And Child Health