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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Synthesis, characterization, antibacterial and cytotoxic study of platinum (IV) complexes
Bioorganic and Medicinal Chemistry, Volume 14, No. 18, Year 2006
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Description
Platinum (IV) complexes [Pt (L)2Cl2] [where, L = benzyl-N-thiohydrazide (L1), (benzyl-N-thio)-1,3-propanediamine (L2), benzaldehyde-benzyl-N-thiohydrazone (L3) and salicylaldehyde-benzyl-N-thiohydrazone (L4)] have been synthesized. The thiohydrazide, thiodiamine and thiohydrazones can exist as thione-thiol tautomer and coordinate as a bidentate N-S ligand. The ligands were found to act in monobasic bidentate fashion. Analytical data reveal that metal to ligand stoichiometry is 1:2. The complexes have been characterized by elemental analysis, IR, mass, electronic and 1H NMR spectroscopic studies. In vitro antibacterial and cytotoxic studies have been carried out for some complexes. Various kinetic and thermodynamic parameters like order of reaction (n), activation energy (Ea), apparent activation entropy (S#) and heat of reaction (ΔH) have also been carried out for some complexes. © 2006 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Mishra, Ajay Kumar
India, New Delhi
University of Delhi
Mishra, Shivani Bhardwaj
South Africa, Bloemfontein
University of the Free State
Manav, Neha
India, New Delhi
University of Delhi
Saluja, Daman
India, New Delhi
Dr. B.r. Ambedkar Center for Biomedical Research
Chandra, Ramesh
India, New Delhi
Dr. B.r. Ambedkar Center for Biomedical Research
Kaushik, Narender Kumar
India, New Delhi
University of Delhi
Statistics
Citations: 24
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.bmc.2006.05.047
ISSN:
09680896