Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
HYPERTHYROIDISM IN GESTATIONAL TROPHOBLASTIC NEOPLASIA
Clinical Endocrinology, Volume 15, No. 4, Year 1981
Notification
URL copied to clipboard!
Description
The thyroid status of twenty‐seven African patients with gestational trophoblastic neoplasia (GTN) was studied. Fifteen patients were found to be biochemically hyperthyroid (eight patients with choriocarcinoma; seven with hydatidiform mole). Of these fifteen patients, nine were clinically thyrotoxic. The most serious complication of thyrotoxicosis was life‐threatening acute pulmonary oedema with associated cardiac failure. It was found that when serum levels of the human chorionic gonadotrophin (hCG) reached a level of about 0·1 ± 106 iu/l, thirteen of sixteen patients were biochemically hyper‐thyroid; at serum levels of 0·3 ± 106 iu/l of hCG most patients were clinically thyrotoxic. A feature of hyperthyroidism associated with GTN is that whereas T4 is invariably raised the T3:T4 ratio tends to be low (0·015 ± 005); rT3:T3 ratios were high in this group. TSH levels were not increased. Copyright © 1981, Wiley Blackwell. All rights reserved
Authors & Co-Authors
Norman, Robert John
South Africa, Durban
University of Kwazulu-natal
Green-Thompson, Ronald W.
South Africa, Durban
University of Kwazulu-natal
Jialal, Ishwarlal
South Africa, Durban
University of Kwazulu-natal
Soutter, William Patrick
South Africa, Durban
University of Kwazulu-natal
PILLAY, N. L.
South Africa, Durban
University of Kwazulu-natal
Joubert, Septimus M.
South Africa, Durban
University of Kwazulu-natal
Statistics
Citations: 54
Authors: 6
Affiliations: 1
Identifiers
Doi:
10.1111/j.1365-2265.1981.tb00680.x
ISSN:
03000664
e-ISSN:
13652265
Research Areas
Noncommunicable Diseases