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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Pentoxifylline as a supportive agent in the treatment of cerebral malaria in children
Journal of Infectious Diseases, Volume 171, No. 5, Year 1995
Notification
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Description
In an open, randomized, controlled therapeutic trial, 56 children with cerebral malaria (CM) were randomly assigned to receive standard Quinine regimen with or without pentoxifylline (10 mg/kg/day by continuous intravenous infusion). Pentoxifylline exerted an inhibitory effect on the synthesis of tumor necrosis factor (TNF), a possible mediator of CM. The 26 children who received pentoxifylline had significantly shorter comas than controls (median, 6 vs. 46 h; P <.001). Pentoxifylline recipients showed a trend toward a lower mortality, with a borderline significant difference (P =.055). The better outcome in the pentoxifylline group was associated with a decline in TNF serum levels on the third day of treatment in a few subjects that was not seen in controls. While alternative or concurrent mechanisms of action may be of some relevance, larger double-blind trials are needed to determine whether pentoxifylline has a therapeutic role in CM. © 1995 by The University of Chicago.
Authors & Co-Authors
Di Perri, Giovanni
Italy, Verona
Università Degli Studi Di Verona
Burundi
Hospital of Kiremba
Di Perri, Haria Guasparri
Italy, Verona
Università Degli Studi Di Verona
Burundi
Hospital of Kiremba
Badona Monteiro, Geraldo Badona
Italy, Verona
Università Degli Studi Di Verona
Burundi
Hospital of Kiremba
Bonora, Stefano
Italy, Verona
Università Degli Studi Di Verona
Burundi
Hospital of Kiremba
Hennig, Cornelia
Italy, Verona
Università Degli Studi Di Verona
Burundi
Hospital of Kiremba
Cassatella, Marco Antonio
Italy, Verona
Università Degli Studi Di Verona
Burundi
Hospital of Kiremba
Micciolo, Rocco
Italy, Verona
Università Degli Studi Di Verona
Burundi
Hospital of Kiremba
Vento, Sandro
Italy, Verona
Università Degli Studi Di Verona
Burundi
Hospital of Kiremba
Dusi, Stella
Italy, Verona
Università Degli Studi Di Verona
Burundi
Hospital of Kiremba
Italy, Verona
Azienda Ospedaliera Universitaria Integrata Verona
Bassetti, Dante
Italy, Verona
Università Degli Studi Di Verona
Burundi
Hospital of Kiremba
Concia, Ercole
Italy, Verona
Università Degli Studi Di Verona
Burundi
Hospital of Kiremba
Statistics
Citations: 100
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1093/infdis/171.5.1317
ISSN:
00221899
e-ISSN:
15376613
Research Areas
Cancer
Disability
Infectious Diseases
Maternal And Child Health