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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Factors associated with chloroquine induced pruritus during malaria treatment in Mozambican University students
Gaceta Sanitaria, Volume 23, No. 4, Year 2009
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Description
Introduction: It has been suggested that reductions in chloroquine use may be followed by a resurgence of chloroquine-susceptible falciparum malaria, and chloroquine might once again be an effective treatment choice, which renews the importance of aspects related to its use and misuse. Therefore, we aimed to estimate the prevalence of chloroquine-induced pruritus and to identify risk factors for its occurrence in Mozambican University students. Methods: A cross-sectional study was conducted at a private University in Maputo. Students were approached in the classrooms to complete a self-administered questionnaire covering sociodemographic characteristics, number of previous malaria episodes, utilization of antimalarial drugs, and life prevalence of chloroquine induced pruritus. Results: Among 795 respondents, 77.4% (601/777) reported at least one malaria episode and 73.2% (542/740) had used chloroquine before. The life-prevalence of chloroquine-induced pruritus was 30.1% (158/525). Pruritus tended to be more frequent when chloroquine was used for treatment compared with prophylaxis only (31.2% vs. 10.3%, p<0.05), and chloroquine use in the last malaria episode was less frequent in participants recalling chloroquine-induced pruritus (52.3% vs. 65.1%, p<0.05). Conclusion: About one third of the black population using chloroquine experienced chloroquine-induced pruritus at least once. This adverse reaction tended to be less frequent when lower doses of chloroquine were used and to influence future anti-malarial therapeutic choices. © 2008 SESPAS.
Authors & Co-Authors
Gama, Helena
Portugal, Porto
Universidade do Porto
Ismael, Aldo
Mozambique, Maputo
Isctem
Sitoi, Felicidade
Mozambique, Maputo
Isctem
Matola, André
Mozambique, Maputo
Isctem
Barros, Henrique P.
Portugal, Porto
Universidade do Porto
Lunet, Nuno
Portugal, Porto
Universidade do Porto
Statistics
Citations: 7
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.gaceta.2008.07.004
ISSN:
02139111
e-ISSN:
15781283
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative