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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Autoimmune subepidermal blistering diseases in Uganda: Correlation of autoantibody class with age of patients
International Journal of Dermatology, Volume 45, No. 9, Year 2006
Notification
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Description
Background: No data are available on the incidence and immunoreactivity of autoimmune subepidermal blistering skin diseases in East Africa. Methods: All patients with frank blisters/erosions on the skin and/or mucous membranes that attended the Department of Dermatology at Mbarara University, Uganda, from May 2000 to June 2002, were investigated. The diagnosis was based on the clinical presentation and on the presence of circulating autoantibodies detected by indirect immunofluorescence microscopy on 1 M NaCl-split human skin and by Western blotting of recombinant and cell-derived forms of BP180, BP230, and type VII collagen. Results: Twenty-two patients with autoimmune subepidermal blistering skin disorders were identified, including nine with bullous pemphigoid (41%), four with linear immunoglobulin A (IgA) disease (18%), three with mucous membrane pemphigoid (14%), two with linear IgG/IgA bullous dermatosis (9%), and one each with cicatricial pemphigoid and epidermolysis bullosa acquisita (5%). In addition, two patients with immunoreactivity to both the epidermal and dermal side of salt-split skin by indirect immunofluorescence microscopy, who were unreactive to type VII collagen, were provisionally diagnosed as "mixed pemphigoid" (9%). In patients with subepidermal blistering diseases, IgG reactivity correlated significantly with old age, whereas younger patients preferentially developed IgA autoantibodies (P = 0.024). Conclusions: The age of patients with autoimmune subepidermal blistering diseases appears to influence the immunoglobulin class of autoantibodies. The high frequency of IgA autoantibodies in Ugandan patients may be explained by the age distribution of the Ugandan population. © 2006 The International Society of Dermatology.
Authors & Co-Authors
Mulyowa, Grace K.
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Uganda, Mbarara
Mbarara University of Science and Technology
Germany, Lubeck
Universitätsklinikum Schleswig-holstein Campus Lübeck
Jaeger, Gerold
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Uganda, Mbarara
Mbarara University of Science and Technology
Germany, Lubeck
Universitätsklinikum Schleswig-holstein Campus Lübeck
Kabakyenga, Jerome Kahuma
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Uganda, Mbarara
Mbarara University of Science and Technology
Germany, Lubeck
Universitätsklinikum Schleswig-holstein Campus Lübeck
Bröcker, Eva Bettina
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Uganda, Mbarara
Mbarara University of Science and Technology
Germany, Lubeck
Universitätsklinikum Schleswig-holstein Campus Lübeck
Zillikens, Detlef
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Uganda, Mbarara
Mbarara University of Science and Technology
Germany, Lubeck
Universitätsklinikum Schleswig-holstein Campus Lübeck
Schmidt, Enno G.
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Uganda, Mbarara
Mbarara University of Science and Technology
Germany, Lubeck
Universitätsklinikum Schleswig-holstein Campus Lübeck
Statistics
Citations: 38
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1111/j.1365-4632.2006.02750.x
ISSN:
00119059
e-ISSN:
13654632
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Multi-countries
Uganda