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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Central haemodynamics reveal significant potential for prevention in Black hypertensive patients born and living in sub-Saharan Africa
Artery Research, Volume 6, No. 1, Year 2012
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Description
Background: Few studies assessed arterial stiffness in Black hypertensive patients born and living in sub-Saharan Africa, where cardiovascular disease reaches epidemic proportions. Methods: The Newer versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) trial is currently recruiting native African patients to compare the efficacy of various antihypertensive drugs given once daily as single-pill combinations. Two centres engaged in pulse wave analysis and measured carotid-femoral pulse wave velocity (PWV). Statistical methods included single and multiple linear regressions. Results: Of 172 patients screened, 116 entered the ancillary study on central haemodynamics (51.3% women; mean age 52.7 years; untreated blood pressure 147.6/87.1. mm. Hg). The augmentation indexes were higher (p< 0.0001) in women than men, both peripherally (pAI, 11.1 vs. -10.6%) and centrally (cAI, 39.0 vs. 28.0%). PWV (8.91. m/s) and central pulse pressure (cPP, 48.7. mm. Hg) were similar (p> 0.844) in both sexes. pAI and cAI increased with female sex and mean arterial pressure, but decreased with heart rate and body mass index. cPP increased with age and mean arterial pressure. PWV increased with age and mean arterial pressure. Patients with measurements above the age-specific thresholds determined in healthy Black South Africans amounted to 0 for cAI, 1 (1.2%) for cPP, and 11 (18.3%) for PWV. Conclusion: NOAAH patients have measures of arterial stiffness similar to those of a healthy Black reference population with determinants as reported in the literature. Our observations highlight the potential for the prevention of irreversible arterial damage by timely treating sub-Saharan hypertensive patients to target blood pressure levels. © 2011.
Authors & Co-Authors
Ezeala-Adikaibe, Birinus
Nigeria, Naukka
University of Nigeria
Belgium, Leuven
Ku Leuven
Liu, Yanping
Belgium, Leuven
Ku Leuven
Lemogoum, Daniel
Nigeria, Abuja
University of Abuja
Anisiuba, Benedict Chukwuemeka
Nigeria, Naukka
University of Nigeria
Kamdem, Marius K.
Nigeria, Abuja
University of Abuja
Kaptue, Joseph
Nigeria, Abuja
University of Abuja
Ijoma, Chinwuba K.
Nigeria, Naukka
University of Nigeria
Thijs, Lutgarde B.
Belgium, Leuven
Ku Leuven
Odili, Augustine Nonso
Belgium, Leuven
Ku Leuven
Cameroon, Douala
Douala School of Medicine
Asayama, Kei
Belgium, Leuven
Ku Leuven
Staessen, Jan A.
Belgium, Leuven
Ku Leuven
Netherlands, Maastricht
Universiteit Maastricht
M'Buyamba-Kabangu, Jean René
Democratic Republic Congo, Kinshasa
Universite de Kinshasa
Ulasi, Ifeoma I.
Nigeria, Naukka
University of Nigeria
Statistics
Citations: 13
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1016/j.artres.2011.11.002
ISSN:
18729312
e-ISSN:
18764401
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Participants Gender
Male
Female