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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Plant-produced cottontail rabbit papillomavirus L1 protein protects against tumor challenge: A proof-of-concept study
Clinical and Vaccine Immunology, Volume 13, No. 8, Year 2006
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Description
The native cottontail rabbit papillomavirus (CRPV) L1 capsid protein gene was expressed transgenically via Agrobacterium tumefaciens transformation and transiently via a tobacco mosaic virus (TMV) vector in Nicotiana spp. L1 protein was detected in concentrated plant extracts at concentrations up to 1.0 mg/kg in transgenic plants and up to 0.4 mg/kg in TMV-infected plants. The protein did not detectably assemble into viruslike particles; however, immunoelectron microscopy showed presumptive pentamer aggregates, and extracted protein reacted with conformation-specific and neutralizing monoclonal antibodies. Rabbits were injected with concentrated protein extract with Freund's incomplete adjuvant. All sera reacted with baculovirus-produced CRPV L1; however, they did not detectably neutralize infectivity in an in vitro assay. Vaccinated rabbits were, however, protected against wart development on subsequent challenge with live virus. This is the first evidence that a plant-derived papillomavirus vaccine is protective in an animal model and is a proof of concept for human papillomavirus vaccines produced in plants. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Kohl, Thomas O.
South Africa, Cape Town
University of Cape Town
South Africa, Cape Town
Faculty of Health Sciences
Hitzeroth, I. I.
South Africa, Cape Town
University of Cape Town
South Africa, Cape Town
Faculty of Health Sciences
Stewart, Deborah
South Africa, Cape Town
Faculty of Health Sciences
Varsani, Arvind
South Africa, Cape Town
University of Cape Town
Govan, Vandana A.
South Africa, Cape Town
Faculty of Health Sciences
Christensen, Neil D.
United States, Hershey
Penn State Cancer Institute
United States, University Park
Pennsylvania State University
Williamson, Anna Lise
South Africa, Cape Town
Faculty of Health Sciences
South Africa, Observatory
Groote Schuur Hospital
Rybicki, Edward P.
South Africa, Cape Town
University of Cape Town
South Africa, Cape Town
Faculty of Health Sciences
Statistics
Citations: 60
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1128/CVI.00072-06
ISSN:
15566811
Research Areas
Cancer
Genetics And Genomics
Substance Abuse