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AFRICAN RESEARCH NEXUS

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immunology and microbiology

A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation

Immunity, Volume 51, No. 4, Year 2019

The mechanisms that protect from febrile malaria remain unclear. Tran et al. applied a systems-based approach to a longitudinal pediatric study to identify immune signatures that associate with control of malaria fever and parasitemia, revealing that p53 upregulation in monocytes attenuates malaria-induced inflammation and predicts protection from fever.

Tran, Tuan M.
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
2. United States, Indianapolis Indiana University School of Medicine
Guha, Rajan
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Portugal, Sílvia
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
2. Germany, Heidelberg Universitätsklinikum Heidelberg
Skinner, Jeff R.
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Ongoïba, Aissata
1. Mali, Bamako University of Sciences
Bhardwaj, Jyoti
1. United States, Indianapolis Indiana University School of Medicine
Jones, Marcus B.
1. United States, Rockville J. Craig Venter Institute
Moebius, Jacqueline
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Venepally, Pratap
1. United States, Rockville J. Craig Venter Institute
Doumbo, Safiatou Niare
1. Mali, Bamako University of Sciences
DeRiso, Elizabeth A.
1. United States, Cambridge Massachusetts Institute of Technology
Li, Shanping
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Vijayan, Kamalakannan
1. United States, Seattle Seattle Biomedical Research Institute
Anzick, Sarah L.
1. United States, Bethesda National Institutes of Health Nih
Hart, Geoffrey Thomas
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
2. United States, Minneapolis University of Minnesota Twin Cities
O'Connell, Elise M.
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid
Doumbo, Ogobara K.
1. Mali, Bamako University of Sciences
Kaushansky, Alexis
1. United States, Seattle Seattle Biomedical Research Institute
Alter, Galit
1. United States, Cambridge Massachusetts Institute of Technology
Felgner, Philip Louis
1. United States, Irvine Uci School of Medicine
Lorenzi, Hernán Alejandro
1. United States, Rockville J. Craig Venter Institute
Kayentao, Kassoum
1. Mali, Bamako University of Sciences
Traoré, Boubacar M.
1. Mali, Bamako University of Sciences
Kirkness, Ewen F.
1. United States, Rockville J. Craig Venter Institute
Crompton, Peter Dobbs
1. United States, Bethesda National Institute of Allergy and Infectious Diseases Niaid

AFRICAN RESEARCH NEXUS

A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation

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African Research Nexus

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AFRICAN RESEARCH NEXUS

A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation

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Authors & Co-Authors

Disclaimer

African Research Nexus

Useful Links