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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Measuring asthma control: A comparison of three classification systems
European Respiratory Journal, Volume 36, No. 2, Year 2010
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Description
There are various ways to classify asthma control; however, no classification is universally accepted. This retrospective analysis compared asthma control as assessed by the Asthma Control Questionnaire (5-item version; ACQ-5), Global Initiative for Asthma (GINA) or Gaining Optimal Asthma Control (GOAL) study criteria. Pooled data at the final study week (n=8,188) from three budesonide/formoterol maintenance and reliever therapy studies which measured ACQ-5 were stratified according to GINA or GOAL criteria and ACQ-5 score distribution. The percentages of patients with a controlled/partly controlled week (GINA), totally/well-controlled week (GOAL) and range of ACQ-5 cut-off points were compared. Patients with GINA controlled, partly controlled and uncontrolled asthma had mean ACQ-5 scores of 0.43, 0.75 and 1.62, respectively. Patients with GOAL totally controlled, well-controlled and uncontrolled asthma had ACQ-5 scores of 0.39, 0.78 and 1.63. The kappa measure of agreement was 0.80 for GINA and GOAL criteria, and 0.63 for GINA controlled/partly controlled and ACQ-5 <1.00. ACQ-5 detected clinically important improvements in 49% of patients who, according to GINA criteria, remained uncontrolled at the end of the study. Asthma control measured by GINA or GOAL criteria provides similar results. GINA Controlled/Partly Controlled and GOAL Totally Controlled/Well- Controlled correspond to ACQ-5 <1.00. The ACQ-5 is more responsive to change in a clinical trial setting than a categorical scale. Copyright©ERS 2010.
Authors & Co-Authors
O'Byrne, Paul M.
Canada, Hamilton
Michael G. Degroote School of Medicine
Canada, Hamilton
Mcmaster University
Reddel, Helen K.
Australia, Sydney
Woolcock Institute of Medical Research
Eriksson, Göran
Sweden, Sodertalje
Astrazeneca Sweden
Sweden, Lund
Skånes Universitetssjukhus
Östlund, Ollie
Sweden, Sodertalje
Astrazeneca Sweden
Peterson, Stefan
Sweden, Sodertalje
Astrazeneca Sweden
Sears, Malcolm R.
Australia, Sydney
Woolcock Institute of Medical Research
Jenkins, Christine R.
Australia, Sydney
Woolcock Institute of Medical Research
Humbert, Marc
France, Gif-sur-yvette
Université Paris-saclay
Buhl, Roland Otto
Germany, Mainz
Universitätsmedizin Mainz
Harrison, Tim W.
United Kingdom, Nottingham
University of Nottingham
Quirce, Santiago
Spain, Madrid
Hospital Universitario la Paz
Bateman, E. D.
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 83
Authors: 12
Affiliations: 10
Identifiers
Doi:
10.1183/09031936.00124009
ISSN:
09031936
e-ISSN:
13993003
Research Areas
Genetics And Genomics
Study Design
Cohort Study