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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Plasma lipid profiles discriminate bacterial from viral infection in febrile children
Scientific Reports, Volume 9, No. 1, Article 17714, Year 2019
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Description
Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The ‘omics’ approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics. © 2019, The Author(s).
Authors & Co-Authors
Wang, Xinzhu
United Kingdom, London
Imperial College London
Nijman, Ruud Gerard
United Kingdom, London
Imperial College London
Camuzeaux, S. S.M.
United Kingdom, London
Imperial College London
Sands, Caroline J.
United Kingdom, London
Imperial College London
Jackson, Heather
United Kingdom, London
Imperial College London
Kaforou, Myrsini
United Kingdom, London
Imperial College London
Emonts, Marieke
United Kingdom, Newcastle
The Newcastle Upon Tyne Hospitals Nhs Foundation Trust
United Kingdom, Newcastle
Newcastle University
Netherlands, Rotterdam
Erasmus Mc
Herberg, Jethro Adam
United Kingdom, London
Imperial College London
Maconochie, Ian
United Kingdom, London
St Mary's Hospital
Carrol, Enitan D.
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Liverpool
Alder Hey Children's Nhs Foundation Trust
United Kingdom, Liverpool
Liverpool Health Partners
Paulus, Stéphane C.
United Kingdom, Liverpool
Alder Hey Children's Nhs Foundation Trust
United Kingdom, Liverpool
Liverpool Health Partners
Zenz, Werner M.
Austria, Graz
Medizinische Universität Graz
van der Flier, Michiel
Netherlands, Utrecht
University Medical Center Utrecht
Netherlands, Nijmegen
Radboud University Medical Center
de Groot, Ronald C.A.
Netherlands, Nijmegen
Radboud University Medical Center
Martinón-Torres, Federico
Spain, Santiago de Compostela
Instituto de Investigación Sanitaria de Santiago de Compostela
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Schlapbach, Luregn J.
Australia, Brisbane
Queensland Children’s Hospital
Pollard, Andrew J.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Fink, Colin G.
United Kingdom, Coventry
University of Warwick
Kuijpers, T. W.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Anderson, Suzanne T.B.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Lewis, Matthew R.
United Kingdom, London
Imperial College London
Levin, Michael L.
United Kingdom, London
Imperial College London
McClure, Myra Olga
United Kingdom, London
Imperial College London
Gormley, Stuart
United Kingdom, London
Imperial College London
Hamilton, Shea
United Kingdom, London
Imperial College London
Hourmat, Bernardo
United Kingdom, London
Imperial College London
Hoggart, Clive J.
United Kingdom, London
Imperial College London
Sancho-Shimizu, Vanessa
United Kingdom, London
Imperial College London
Wright, Victoria J.
United Kingdom, London
Imperial College London
Abdulla, Amina F.
United Kingdom, London
Imperial College London
Agapow, Paul Michael
United Kingdom, London
Imperial College London
Bartlett, Maeve
United Kingdom, London
Imperial College London
Bellos, Evangelos
United Kingdom, London
Imperial College London
Eleftherohorinou, Hariklia
United Kingdom, London
Imperial College London
Galassini, Rachel
United Kingdom, London
Imperial College London
Inwald, David Philip
United Kingdom, London
Imperial College London
Mashbat, Meg
United Kingdom, London
Imperial College London
Menikou, Stephanie
United Kingdom, London
Imperial College London
Mustafa, Sobia
United Kingdom, London
Imperial College London
Nadel, Simon
United Kingdom, London
Imperial College London
Rahman, Rahmeen
United Kingdom, London
Imperial College London
Thakker, Clare
United Kingdom, London
Imperial College London
Coin, Lachlan J.M.
United Kingdom, London
Imperial College London
Bokhandi, Sumit S.
United Kingdom, Poole
University Hospitals Dorset Nhs Foundation Trust
Power, Sue
United Kingdom, Poole
University Hospitals Dorset Nhs Foundation Trust
Barham, Heather
United Kingdom, Poole
University Hospitals Dorset Nhs Foundation Trust
Ridout, Jenna A.
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
White, Deborah K.
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Thurston, Sarah
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Faust, Saul N.
United Kingdom, Southampton
University Hospital Southampton Nhs Foundation Trust
Patel, Sanjay Valabh
United Kingdom, Southampton
University Hospital Southampton Nhs Foundation Trust
McCorkell, Jenni
United Kingdom, Southampton
University Hospital Southampton Nhs Foundation Trust
Davies, Patrick R.F.
United Kingdom, Nottingham
Nottingham University Hospitals Nhs Trust
Crate, Lindsay
United Kingdom, Nottingham
Nottingham University Hospitals Nhs Trust
Navarra, Helen
United Kingdom, Nottingham
Nottingham University Hospitals Nhs Trust
Carter, Stephanie
United Kingdom, Nottingham
Nottingham University Hospitals Nhs Trust
Ramaiah, Raghu
United Kingdom, Leicester
University Hospitals of Leicester Nhs Trust
Patel, Rekha
United Kingdom, Leicester
University Hospitals of Leicester Nhs Trust
Tuffrey, Catherine
United Kingdom, Portsmouth
Portsmouth Hospitals University Nhs Trust
Gribbin, Andrew
United Kingdom, Portsmouth
Portsmouth Hospitals University Nhs Trust
McCready, Sharon
United Kingdom, Portsmouth
Portsmouth Hospitals University Nhs Trust
Peters, Mark John
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Hardy, Katie
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Standing, Fran
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
O’Neill, Lauran
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Abelake, Eugenia
United Kingdom, London
Great Ormond Street Hospital for Children Nhs Foundation Trust
Deep, Akash
United Kingdom, London
King's College Hospital Nhs Foundation Trust
Nsirim, Eniola
United Kingdom, London
King's College Hospital Nhs Foundation Trust
Willis, Louise
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Young, Zoe
United Kingdom, Oxford
Oxford University Hospitals Nhs Foundation Trust
Royad, C.
United Kingdom, Kettering
Kettering General Hospital Nhs Foundation Trust
White, Sonia
United Kingdom, Kettering
Kettering General Hospital Nhs Foundation Trust
Fortune, Peter Marc
United Kingdom, Manchester
Manchester University Nhs Foundation Trust
Hudnott, Phil
United Kingdom, Manchester
Manchester University Nhs Foundation Trust
González, Fernando Álvez
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Barral-Arca, Ruth
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Instituto de Investigación Sanitaria de Santiago de Compostela
Cebey-López, Miriam
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Currás-Tuala, María José
United Kingdom, London
Imperial College London
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
García, Natalia
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Vicente, Luisa García
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Gõmez-Carballa, Alberto
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Instituto de Investigación Sanitaria de Santiago de Compostela
Rial, Jose Gómez
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Beiroa, Andrea Grela
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Grande, Antonio Justicia
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Iglesias, Pilar Leboráns
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Santos, Alba Elena Martínez
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Sánchez, José María
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Pérez, Belén Mosquera
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Pacheco, Pablo Obando
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Pardo-Seco, Jacobo
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Instituto de Investigación Sanitaria de Santiago de Compostela
Pischedda, Sara
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Instituto de Investigación Sanitaria de Santiago de Compostela
Rodríguez-Tenreiro, Carmen
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Redondo Collazo, Lorenzo
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Fernández, Sonia Serén
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Silva, María Del Sol Porto
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Vega, Ana Karina
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Instituto de Investigación Sanitaria de Santiago de Compostela
Salas, Antonio
Spain, Santiago de Compostela
Hospital Clínico Universitario de Santiago
Spain, Santiago de Compostela
Instituto de Investigación Sanitaria de Santiago de Compostela
Reyes, Susana Beatriz
Spain, Murcia
Hospital Clínico Universitario Virgen de la Arrixaca
Torre, Andrés Concha
Spain, Oviedo
Hospital Universitario Central de Asturias
Sánchez, Francisco Giménez
Spain, Almeria
Complejo Hospitalario Torrecardenas de Almeria
Rojo, Pablo
Spain, Madrid
Hospital Universitario 12 de Octubre
Navarro, Marisa Luisa
Spain, Madrid
Hospital General Universitario Gregorio Marañón
Prieto, Luis M.
Spain, Getafe
Hospital Universitario de Getafe
Guillén Martín, Sara
Spain, Getafe
Hospital Universitario de Getafe
Van Furth, A. M.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Boeddha, Navin P.
Netherlands, Rotterdam
Erasmus Mc
Driessen, Gertjan Jan A.
Netherlands, Rotterdam
Erasmus Mc
Hazelzet, Jan A.
Netherlands, Rotterdam
Erasmus Mc
Pajkrt, Dasja
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Sanders, Elisabeth A.M.(Elisabeth)
Netherlands, Utrecht
University Medical Center Utrecht
van de Beek, Diederik V.D.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
van der Ende, Arie D.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
de Vries, Esther
Netherlands, 's-hertogenbosch
Jeroen Bosch Hospital
Netherlands, Utrecht
Diakonessenhuis Utrecht
Jansen, Nicolaas Johannes Georgius
Netherlands, Utrecht
University Medical Center Utrecht
Kneyber, Martin Christiaan Jacques
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Noordzij, Jeroen G.
Netherlands, Delft
Reinier de Graaf Hospital - Ssdz
Obihara, Charlie C.C.
Unknown Affiliation
van Wermeskerken, Anne Marie
Unknown Affiliation
Wolfs, Tom F.W.
United Kingdom, Newcastle
Newcastle University
Agyeman, Philipp Kwame Abayie
Switzerland, Bern
University of Bern
Berger, Christoph Tobias
Switzerland, Bern
University of Bern
Switzerland, Zurich
Kinderspital Zürich
Pósfay-Barbe, Klara Maria
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Heininger, Ulrich
Switzerland, Basel
Universitäts-kinderspital Beider Basel
Kahlert, Christian R.
Switzerland, St Gallen
Children's Hospital of Eastern Switzerland
Jennings, Rebecca J.
United Kingdom, Liverpool
Alder Hey Children's Hospital
Pinnock, Ellie
United Kingdom, Coventry
University of Warwick
Agbeko, Rachel Sarah
United Kingdom, Newcastle
Newcastle University
United Kingdom, London
St Mary's Hospital
Secka, Fatou
Gambia, Banjul
Medical Research Council Laboratories Gambia
Bojang, Kalifa A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Sarr, Isatou
Gambia, Banjul
Medical Research Council Laboratories Gambia
Kebbeh, Ngange
Gambia, Banjul
Medical Research Council Laboratories Gambia
Sey, Gibbi
Gambia, Banjul
Medical Research Council Laboratories Gambia
Antonio, Martin
Gambia, Banjul
Medical Research Council Laboratories Gambia
Klobassa, Daniela Sabine
Netherlands, Utrecht
University Medical Center Utrecht
Binder, Alexander
Netherlands, Utrecht
University Medical Center Utrecht
Schweintzger, Nina Alexandra
Netherlands, Utrecht
University Medical Center Utrecht
Sagmeister, Manfred G.
Netherlands, Utrecht
University Medical Center Utrecht
Behrends, Uta
Germany, Munich
Technische Universität München
Brunner, Jürgen K.H.
Austria, Innsbruck
Medizinische Universitat Innsbruck
Eber, Ernst
Austria, Graz
Medizinische Universität Graz
Elias, Johannes
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Kohlmaier, Benno
Austria, Graz
Medizinische Universität Graz
Komini, Eleni
Germany, Villingen-schwenningen
Schwarzwald-baar Hospital
Reiter, Karl
Germany, Munich
Ludwig-maximilians-universität München
Sperl, Matthias
Austria, Graz
Medizinische Universität Graz
Till, Holger Karl H.
Austria, Graz
Medizinische Universität Graz
Trobisch, Andreas
Austria, Graz
Medizinische Universität Graz
Vogel, Ulrich
Austria, Graz
Medizinische Universität Graz
Wintergerst, Uwe
Austria, Braunau
St Josef Hospital
Statistics
Citations: 13
Authors: 149
Affiliations: 98
Identifiers
Doi:
10.1038/s41598-019-53721-1
ISSN:
20452322
Research Areas
Maternal And Child Health
Noncommunicable Diseases