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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Plasmodium falciparum: Sensitivity to chloroquine in vivo in three ecological zones in Ghana
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 86, No. 3, Year 1992
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Description
4690 children aged 6-15 years in 5 urban and 4 rural communities in 3 ecological zones in Ghana were screened from June 1988 to December 1990 to provide suitable candidates for the World Health Organization standard in vivo test for susceptibility of Plasmodium falciparum to chloroquine. 1880 (40•1%) had para- sitaemia, mostly (83•7-98•6%) due to P. falciparum infection. Of the 626 in vivo tests performed, 570 (91•1%) showed sensitivity to chloroquine and 56 (8•9%) responses were classified as resistant to chloroquine at RI (5•1%) and RII (3•8%). The resistance responses were commonest (17•1-22•7%) in the coastal zone, followed by the savanna zone (8•6-10•0%), and lowest in the forest zone (3•1-6•3%). The RII responses occurred mainly in communities in the coastal zone. There was no RIII resistance in any zone. The pattern of RI (early) and RII responses of P. falciparum to chloroquine in this study suggested an increase in sensitivity, or a reduction in resistance, of P. falciparum to chloroquine from the coast to the forest and northern savanna zones, and from the urban to the rural communities in each zone in Ghana. © Oxford University Press.
Authors & Co-Authors
Afari, Edwin Andrew
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Akanmori, Bartholomew Dicky
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Nakano, T.
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Ofori‐Adjei, David
Ghana, Accra
University of Ghana
Statistics
Citations: 48
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/0035-9203(92)90285-K
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Maternal And Child Health
Study Locations
Ghana