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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Autosplenectomy of sickle cell disease in Zaria, Nigeria: An ultrasonographic assessment
Oman Medical Journal, Volume 27, No. 2, Year 2012
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Description
Objectives: During infancy and early childhood, the spleen commonly enlarges in patients with sickle cell anemia (SCA), and it thereafter undergoes progressive atrophy due to repeated episodes of vaso-occlusion and infarction, leading to autosplenectomy in adult life. However, this may not always be the case as some studies have reported splenomegaly persisting into adult life. This study aims to determine and review the prevalence of autosplenectomy by abdominal ultrasonography in sickle cell anemic patients in Zaria, Nigeria. Methods: An ex-post-facto cross study of 74 subjects was carried out between May to July in 2010. Hematological parameters were determined by an analyzer while B mode Ultrasonography was used to determine the craniocaudal length of the spleen, if visualized. Results: The mean age of the sickle cell subjects was 23.2 ±5.3 years, while that of the controls was 22.7±12.4 years. Of the 74 sickle cell subjects, 55.4% were females; while of the 20 controls, 50% were females. Forty one subjects (55.4%) had autosplenectomy and a significant difference existed in the mean splenic size compared with the control (p<0.0001). Only 3 (4.05%) subjects had splenomegaly, while 23 (31%) had a shrunken spleen. Conclusion: Anatomical autosplenectomy is not an uncommon finding in SCA patients. This may be related to inadequate clinical care due to the lack of good health education, ignorance, poverty, and poor standard of care, as well as the lack of newer therapeutic agents. © OMSB, 2012.
Authors & Co-Authors
Babadoko, Ahmadu Aliyu
Nigeria, Zaria
Ahmadu Bello University
Ibinaye, Philip O.
Nigeria, Zaria
Ahmadu Bello University
Hassan, Abdulaziz S.
Nigeria, Zaria
Ahmadu Bello University
Yusuf, R. J.
Nigeria, Zaria
Ahmadu Bello University
Ijei, Ifeoma P.
Nigeria, Zaria
Ahmadu Bello University
Aiyekomogbon, Joshua Oluwafemi
Nigeria, Zaria
Ahmadu Bello University
Aminu, Sirajo Mohammed
Nigeria, Zaria
Ahmadu Bello University
Hamidu, Ahmed Umdagas
Nigeria, Zaria
Ahmadu Bello University
Statistics
Citations: 34
Authors: 8
Affiliations: 1
Identifiers
Doi:
10.5001/omj.2012.25
ISSN:
1999768X
e-ISSN:
20705204
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Nigeria
Participants Gender
Female