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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Microtubule organizing centers regulate spindle positioning in mouse oocytes
Developmental Cell, Volume 57, No. 2, Year 2022
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Description
During female meiosis I (MI), spindle positioning must be tightly regulated to ensure the fidelity of the first asymmetric division and faithful chromosome segregation. Although the role of F-actin in regulating these critical processes has been studied extensively, little is known about whether microtubules (MTs) participate in regulating these processes. Using mouse oocytes as a model system, we characterize a subset of MT organizing centers that do not contribute directly to spindle assembly, termed mcMTOCs. Using laser ablation, STED super-resolution microscopy, and chemical manipulation, we show that mcMTOCs are required to regulate spindle positioning and faithful chromosome segregation during MI. We discuss how forces exerted by F-actin on the spindle are balanced by mcMTOC-nucleated MTs to anchor the spindle centrally and to regulate its timely migration. Our findings provide a model for asymmetric cell division, complementing the current F-actin-based models, and implicate mcMTOCs as a major player in regulating spindle positioning. © 2021 Elsevier Inc.
Authors & Co-Authors
Behura, Susanta K.
United States, Columbia
University of Missouri
Balboula, Ahmed Z.
United States, Columbia
University of Missouri
United Kingdom, Cambridge
University of Cambridge
Statistics
Citations: 9
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1016/j.devcel.2021.12.011
ISSN:
15345807
Participants Gender
Female