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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Gene copy number variations in breast cancer of Sub-Saharan African women
Breast, Volume 22, No. 3, Year 2013
Notification
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Description
The goal of this study was CGH array profiling of breast cancer from Malian women in order to define differences with those from USA. CGH array was performed in 28 samples, 17 with a triple negative phenotype. The profiles were compared to those of 106 tumors from USA. 6 chromosomal regions (6p21, 9q34, 11q13, 12q24, 17q25 and 22q12.1-22q13.1) were identified with a significant higher rate of copy number alterations. These regions contain several genes of interest including BCR. FISH and IHC confirmed that BCR was amplified and overexpressed particularly in triple negative tumors. Finally, 5 regions presented a high level of amplification in two or more samples, including 2 regions located between 9p22.3-9p23 and 9p23-9p24.1. This study confirms that breast cancers from African women present biological differences with those from USA. Larger studies are needed to go further in the identification of therapeutic targets that would be specific to African women. © 2012 Elsevier Ltd.
Authors & Co-Authors
Ly, Madani
Mali, Bamako
Hopital National du Point g
France, Paris
Sorbonne Université
Valent, A.
France, Villejuif
Institut de Cancerologie Gustave Roussy
Diallo, Gangaly
Mali, Bamako
Chu Gabriel Touré
Pénault-Llorca, Fréd́erique M.
France, Clermont-ferrand
Centre Jean Perrin
Dumke, K.
Germany, Munster
University of Münster
Marty, Virginie
France, Villejuif
Institut de Cancerologie Gustave Roussy
Viehl, Philippe
France, Villejuif
Institut de Cancerologie Gustave Roussy
Lazar, Vladimir
France, Villejuif
Institut de Cancerologie Gustave Roussy
Job, Bastien
France, Villejuif
Institut de Cancerologie Gustave Roussy
Richon, Catherine
France, Villejuif
Institut de Cancerologie Gustave Roussy
Scott, Veronique
France, Villejuif
Institut de Cancerologie Gustave Roussy
Diallo, Dapa Aly
Mali, Bamako
Hopital National du Point g
Bernaudin, Jean François
France, Paris
Sorbonne Université
André, Fabrice
France, Villejuif
Institut de Cancerologie Gustave Roussy
France, Villejuif
Prédicteurs Moléculaires et Nouvelles Cibles en Oncologie
Statistics
Citations: 14
Authors: 14
Affiliations: 7
Identifiers
Doi:
10.1016/j.breast.2012.07.010
ISSN:
09609776
Research Areas
Cancer
Genetics And Genomics
Participants Gender
Female