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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The role of the forkhead transcription factor, Foxc1, in the development of the mouse lacrimal gland
Developmental Dynamics, Volume 235, No. 4, Year 2006
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Description
The lacrimal gland produces secretions that lubricate and protect the cornea of the eye. Foxc1 encodes a forkhead/winged helix transcription factor required for the development of many embryonic organs. Autosomal dominant mutations in human FOXC1 cause eye disorders such as Axenfeld-Rieger Syndrome and glaucoma iris hypoplasia, resulting from malformation of the anterior segment of the eye. We show here that lacrimal gland development is severely impaired in homozygous null Foxc1 mouse mutants, with reduced outgrowth and branching. Foxc1 is expressed in both the epithelium of the lacrimal gland and the surrounding mesenchyme. FGF10 stimulates the growth and branching morphogenesis in cultures of wild type and Foxc1 mutant gland epithelial buds. However, using micromass culture of lacrimal gland mesenchyme, we show that Bmp7 induces wild type mesenchyme cells to aggregate, but Foxc1 mutant cells do not respond. This study demonstrates that Foxc1 mediates the BMP signaling required for lacrimal gland development. © 2006 Wiley-Liss, Inc.
Authors & Co-Authors
Mattiske, Deidre
United States, Durham
Duke University Medical Center
Sommer, Paula
South Africa, Cape Town
University of Cape Town
Kidson, Susan Hillary
South Africa, Cape Town
University of Cape Town
Hogan, Brigid L.M.
United States, Durham
Duke University Medical Center
Statistics
Citations: 24
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1002/dvdy.20702
ISSN:
10588388
e-ISSN:
10970177
Research Areas
Health System And Policy