Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The Lambaréné Organ Dysfunction Score (LODS) is a simple clinical predictor of fatal malaria in African children
Journal of Infectious Diseases, Volume 200, No. 12, Year 2009
Notification
URL copied to clipboard!
Description
Background. Plasmodium falciparum malaria accounts for >1 million deaths annually, mostly among young children in sub-Saharan Africa. Identifying those individuals who are likely to die is crucial. Several factors have been independently associated with death. Because malaria is a systemic disease, a quantitative score combining such risk factors may be superior. Methods. We used both forward and backward stepwise logistic regression to select the best predictors of death, as evaluated for 23,890 African children with severe P. falciparum malaria. The study was conducted from December 2000 through May 2005 in 6 hospital-based research units (in Banjul in the Gambia, Blantyre in Malawi, Kilifi in Kenya, Kumasi in Ghana, and Lambaréné and Libreville in Gabon) in a network established to study severe malaria in African children (ie, the SMAC Network). Results. The Lambaréné Organ Dysfunction Score (LODS) combines 3 variables: coma, prostration, and deep breathing. A LODS >0 (odd ratio, 9.6; 95% confidence interval, 8.0-11.4) has 85% sensitivity to predict death, and a LODS <3 is highly (98%) specific for survival. Conclusions. The LODS is a simple clinical predictor of fatal malaria in African children. This score provides accurate and rapid identification of children needing either referral or increased attention. © 2009 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Helbok, Raimund
Unknown Affiliation
Kendjo, Éric
Unknown Affiliation
Issifou, Saadou
Unknown Affiliation
Lackner, Peter
Unknown Affiliation
Newton, Charles R.J.C.
Unknown Affiliation
Kombila, Maryvonne Y.
Unknown Affiliation
Agbenyega, Tsiri E.
Unknown Affiliation
Bojang, Kalifa A.
Unknown Affiliation
Dietz, Klaus
Unknown Affiliation
Schmutzhard, Erich
Unknown Affiliation
Kremsner, Peter G.
Unknown Affiliation
Statistics
Citations: 67
Authors: 11
Affiliations: 11
Identifiers
Doi:
10.1086/648409
ISSN:
00221899
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Approach
Quantitative
Study Locations
Gabon
Gambia
Ghana
Kenya
Malawi