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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Treatment failure in a typhoid patient infected with nalidixic acid resistant S. enterica serovar Typhi with reduced susceptibility to ciprofloxacin: A case report from Cameroon
BMC Infectious Diseases, Volume 5, Article 49, Year 2005
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Description
Background: Fluoroquinolones or third generation cephalosporins are the drugs of choice for the treatment of typhoid fever. Treatment failure with fluoroquinolones has been reported in Asia and Europe. We report a case of ciprofloxacin treatment failure in typhoid fever in Cameroon. Case presentation: A 29-year-old female patient with suspected typhoid fever from Kumba, Cameroon, yielded growth of Salmonella enterica serovar Typhi in blood culture. The isolate was resistant to nalidixic acid but sensitive to ciprofloxacin by disc diffusion test. However, the patient did not respond to treatment with ciprofloxacin, although the isolate was apparently susceptible to ciprofloxacin. Conclusion: Treatment failure with ciprofloxacin in our case indicates the presence of nalidixic acid resistant S. enterica serovar Typhi (NARST) with reduced susceptibility to ciprofloxacin in Cameroon (Central Africa). © 2005 Nkemngu et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Nkemngu, Njinkeng Joseph
Cameroon
St. John's Maternity and Hospital
Cameroon
St. Joseph's Medical Centre
Asonganyi, Etienne D.N.
Cameroon
St. Joseph's Medical Centre
Cameroon, Yaounde
Université de Yaoundé I
Njunda, Anna Longdoh
Cameroon, Buea
University of Buea
Statistics
Citations: 32
Authors: 3
Affiliations: 4
Identifiers
Doi:
10.1186/1471-2334-5-49
ISSN:
14712334
e-ISSN:
14712334
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Cameroon
Participants Gender
Female