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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Global burden of respiratory infections due to seasonal influenza in young children: A systematic review and meta-analysis
The Lancet, Volume 378, No. 9807, Year 2011
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Description
The global burden of disease attributable to seasonal influenza virus in children is unknown. We aimed to estimate the global incidence of and mortality from lower respiratory infections associated with influenza in children younger than 5 years. We estimated the incidence of influenza episodes, influenza-associated acute lower respiratory infections (ALRI), and influenza-associated severe ALRI in children younger than 5 years, stratified by age, with data from a systematic review of studies published between Jan 1, 1995, and Oct 31, 2010, and 16 unpublished population-based studies. We applied these incidence estimates to global population estimates for 2008 to calculate estimates for that year. We estimated possible bounds for influenza-associated ALRI mortality by combining incidence estimates with case fatality ratios from hospital-based reports and identifying studies with population-based data for influenza seasonality and monthly ALRI mortality. We identified 43 suitable studies, with data for around 8 million children. We estimated that, in 2008, 90 million (95 CI 49-162 million) new cases of influenza (data from nine studies), 20 million (13-32 million) cases of influenza-associated ALRI (13 of all cases of paediatric ALRI; data from six studies), and 1 million (1-2 million) cases of influenza-associated severe ALRI (7 of cases of all severe paediatric ALRI; data from 39 studies) occurred worldwide in children younger than 5 years. We estimated there were 28 000-111 500 deaths in children younger than 5 years attributable to influenza-associated ALRI in 2008, with 99 of these deaths occurring in developing countries. Incidence and mortality varied substantially from year to year in any one setting. Influenza is a common pathogen identified in children with ALRI and results in a substantial burden on health services worldwide. Sufficient data to precisely estimate the role of influenza in childhood mortality from ALRI are not available. WHO; Bill & Melinda Gates Foundation. © 2011 Elsevier Ltd.
Authors & Co-Authors
Nair, Harish
United Kingdom, Edinburgh
The University of Edinburgh
India, New Delhi
Public Health Foundation of India
Brooks, W. Abdullah
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Katz, Mark A.
Kenya, Kisumu
Centers for Disease Control and Prevention, Kenya
Roca, Anna
Spain, Barcelona
Universitat de Barcelona
Mozambique, Maputo
Centro de Investigaão em Saúde da Manhia
Berkley, James A.
Kenya, Kilifi
Centre for Geographic Medicine Research
United Kingdom, Oxford
University of Oxford
Madhi, Shabir A.
South Africa, Johannesburg
University of the Witwatersrand
Simmerman, James Mark
Thailand, Nontaburi
Thailand Ministry of Public Health
Gordon, Aubree L.
United States, Berkeley
University of California, Berkeley
United States, Bethesda
Fogarty International Center
Sato, Masatoki
Japan, Fukushima
Fukushima Medical University
Howie, Stephen R.C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Krishnan, Anand
India, New Delhi
All India Institute of Medical Sciences, new Delhi
Ope, Maurice O.
Kenya, Nairobi
Ministry of Public Health and Sanitation
Lindblade, Kim A.
United States, Atlanta
Centers for Disease Control and Prevention
Carosone-Link, Phyllis J.
United States, Denver
University of Colorado Denver
Lucero, Marilla G.
Philippines, Manila
Research Institute for Tropical Medicine
Ochieng, Walter Onalo
Kenya, Nairobi
Kenya Medical Research Institute
Kamimoto, Laurie A.
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Dueger, Erica L.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Bhat, Niranjan
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Vong, Sirenda
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Theodoratou, Evropi
United Kingdom, Edinburgh
The University of Edinburgh
Chittaganpitch, Malinee
Thailand, Nontaburi
Thailand Ministry of Public Health
Chimah, Osaretin U.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Nigeria
Federal Medical Centre Nigeria
Balmaseda, Ángel
Nicaragua, Managua
Ministry of Health
Buchy, Philippe
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Harris, Eva H.
United States, Berkeley
University of California, Berkeley
Evans, Valerie
United Kingdom, Edinburgh
The University of Edinburgh
Katayose, Masahiko
Japan, Soma
Soma General Hospital
Gaur, Bharti
India, New Delhi
All India Institute of Medical Sciences, new Delhi
O'Callaghan-Gordo, Cristina
Spain, Barcelona
Universitat de Barcelona
Mozambique, Maputo
Centro de Investigaão em Saúde da Manhia
Goswami, Doli Rani
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Arvelo, Wences
United States, Atlanta
Centers for Disease Control and Prevention
Venter, Marietjie
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Pretoria
University of Pretoria
Briese, Thomas C.
United States, New York
Mailman School of Public Health
Tokarz, Rafal
United States, New York
Mailman School of Public Health
Widdowson, Marc Alain
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Mounts, Anthony Wayne
Switzerland, Geneva
Organisation Mondiale de la Santé
Breiman, Robert F.
Kenya, Kisumu
Centers for Disease Control and Prevention, Kenya
Feikin, Daniel R.
Kenya, Kisumu
Centers for Disease Control and Prevention, Kenya
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Klugman, K. P.
South Africa, Johannesburg
University of the Witwatersrand
United States, Atlanta
Rollins School of Public Health
Olsen, Sonja Julia
Thailand, Nontaburi
Thailand Ministry of Public Health
Gessner, Bradford D.
France, Paris
Agence de Médecine Préventive
Wright, Peter F.
United States, Hanover
Geisel School of Medicine at Dartmouth
Rudan, Igor
United Kingdom, Edinburgh
The University of Edinburgh
Croatia, Split
School of Medicine, University of Split
Broor, Shobha L.
India, New Delhi
All India Institute of Medical Sciences, new Delhi
Simoẽs, Eric A.F.
United States, Denver
University of Colorado Denver
Indonesia, Bandung
University of Padjadjaram
Campbell, Harry
United Kingdom, Edinburgh
The University of Edinburgh
Statistics
Citations: 844
Authors: 47
Affiliations: 36
Identifiers
Doi:
10.1016/S0140-6736(11)61051-9
ISSN:
01406736
e-ISSN:
1474547X
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Systematic review