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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Data-driven networking of global transcriptomics and male sexual development in the main malaria vector, Anopheles funestus
Scientific Reports, Volume 13, No. 1, Article 16798, Year 2023
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Description
Deaths from malaria remain staggering despite global support that drives research into new territories. One major gap is our understanding of the sexual biological aspects of the male mosquito, which maintain the vector population solidity. Although Anopheles funestus s.s. is an extremely efficient African vector, little is known about the network between its sexual physiology and gene expression. The Culicidae male’s sexual maturity involves a suite of physiological changes, such as genitalia rotation that is necessary for successful mating to occur. We show that mating success is guided by genes and physiological plasticity. Transcriptome analysis between newly emerged males (immature) versus males with rotating genitalia (maturing) provides insight into possible molecular mechanisms regulating male sexual behaviour. Putative transcripts that were associated with male sexual maturation were identified and validated. The discovery of the functions of these transcripts could lead to identifying potential targets for innovative vector control interventions, and mosquito population suppression. © 2023, Springer Nature Limited.
Authors & Co-Authors
Koekemoer, Lizette Leonie
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
South Africa, Johannesburg
National Health Laboratory Service
Hajkazemian, Melika
Sweden, Stockholm
Stockholms Universitet
Zawada, Jacek W.
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
South Africa, Johannesburg
National Health Laboratory Service
Mirzaie, Mehdi
Finland, Helsinki
Helsingin Yliopisto
Dahan-Moss, Yael Leah
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
South Africa, Johannesburg
National Health Laboratory Service
Emami, Seyedeh Noushin
Sweden, Stockholm
Stockholms Universitet
Sweden, Stockholm
Molecular Attraction ab
United Kingdom, London
University of Greenwich
Statistics
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1038/s41598-023-43914-0
ISSN:
20452322
Research Areas
Genetics And Genomics
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Participants Gender
Male