Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The effects of male aging on semen quality, sperm DNA fragmentation and chromosomal abnormalities in an infertile population
Journal of Assisted Reproduction and Genetics, Volume 28, No. 5, Year 2011
Notification
URL copied to clipboard!
Description
Purpose: To investigate the effects of male aging on semen quality, DNA fragmentation and chromosomal abnormalities in the spermatozoa of infertile patients and fertile men. Methods: Semen samples of 140 infertile patients (24-76 years) and 50 men with proven fertility (25-65 years) were analyzed according to WHO guidelines. DNA fragmentation was detected by TUNEL assay, while aneuploidy was assessed by FISH. Results: In the patient group, semen volume and vitality of spermatozoa decreased significantly with age, while sperm concentration showed a statistically significant increase with age. DNA fragmentation as well as disomy of sex chromosomes and disomy 8 did not show a statistically significant change with age. However, the diploidy rate was significantly increased with patient's age. In the control group, conventional semen parameters as well as DNA fragmentation and chromosomal abnormalities did not show a statistically significant with age. Conclusion: Increased age in infertile men is associated with an increase in sperm concentration and diploidy, as well as a decline in semen volume and sperm vitality. However motility, morphology and DNA fragmentation are not affected by male age. © 2011 Springer Science+Business Media, LLC.
Authors & Co-Authors
Brahem, Sonia
Tunisia, Sousse
University Teaching Hospital
Mehdi, Meriem
Tunisia, Sousse
University Teaching Hospital
Elghèzal, Hatem M.
Tunisia, Sousse
University Teaching Hospital
Saâd, Ali
Tunisia, Sousse
University Teaching Hospital
Statistics
Citations: 100
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1007/s10815-011-9537-5
ISSN:
10580468
Research Areas
Genetics And Genomics
Health System And Policy
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cross Sectional Study
Participants Gender
Male