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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Improved hatching in mouse embryos brought about by combined partial zona dissection and co-culture
Human Reproduction, Volume 8, No. 4, Year 1993
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Description
In this study 874 mouse embryos were allocated to six groups including a control, co-culture, and four groups that underwent partial zona dissection (PZD): at the 2-cell (PZD-2) and morula stages (PZD-M) both with and without co-culture. Rates of complete blastocyst hatching on day 5 increased in the following order: control, co-culture alone, PZD-2 alone, PZD-M alone, PZD-2 with co-culture and PZD-M with co-culture (P < 0.00001). PZD-M led to significantly higher rates of complete blastocyst hatching compared to PZD-2 (P < 0.03). This study showed also that co-culture apparently compensates for any minor damage incurred during the PZD technique at the 2-cell and morula stages, (P < 0.01 and P < 0.01) respectively. Therefore PZD and co-culture seem mutually beneficial techniques that promote early blastocyst hatching in the mouse. © 1993 Oxford University Press.
Authors & Co-Authors
Khalifa, Essam Al Dein M.A.
United States, Atlanta
Reproductive Biology Associates
Egypt, Asyut
Assiut University
Tucker, Michael J.
United States, Atlanta
Reproductive Biology Associates
Hunt, Patricia
United States, Atlanta
Emory University
Hamidi, Jamal
United States, Atlanta
Reproductive Biology Associates
Statistics
Citations: 16
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1093/oxfordjournals.humrep.a138103
ISSN:
02681161