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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
HIV-1 populations in semen arise through multiple mechanisms
PLoS Pathogens, Volume 6, No. 8, Article e1001053, Year 2010
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Description
HIV-1 is present in anatomical compartments and bodily fluids. Most transmissions occur through sexual acts, making virus in semen the proximal source in male donors. We find three distinct relationships in comparing viral RNA populations between blood and semen in men with chronic HIV-1 infection, and we propose that the viral populations in semen arise by multiple mechanisms including: direct import of virus, oligoclonal amplification within the seminal tract, or compartmentalization. In addition, we find significant enrichment of six out of nineteen cytokines and chemokines in semen of both HIV-infected and uninfected men, and another seven further enriched in infected individuals. The enrichment of cytokines involved in innate immunity in the seminal tract, complemented with chemokines in infected men, creates an environment conducive to T cell activation and viral replication. These studies define different relationships between virus in blood and semen that can significantly alter the composition of the viral population at the source that is most proximal to the transmitted virus. © 2010 Anderson et al.
Available Materials
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https://efashare.b-cdn.net/share/pmc/articles/PMC2924360/bin/ppat.1001053.s002.tif
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https://efashare.b-cdn.net/share/pmc/articles/PMC2924360/bin/ppat.1001053.s017.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC2924360/bin/ppat.1001053.s018.xls
Authors & Co-Authors
Anderson, Jeffrey A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Ping, Lihua
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Dibben, Oliver
United Kingdom, Compton
Edward Jenner Institute for Vaccine Research
Jabara, Cassandra B.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Arney, Leslie A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Kincer, Laura Pesci
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Tang, Yuyang
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Hobbs, Marcia M.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Hoffman, Irving F.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Kazembe, Peter Nicholas
Malawi
Baylor Pediatric Center of Excellence
Jones, Corbin D.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Borrow, Persephone
United Kingdom, Compton
Edward Jenner Institute for Vaccine Research
Fiscus, Susan A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Cohen, Myron S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Swanstrom, Ronald I.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Statistics
Citations: 137
Authors: 15
Affiliations: 3
Identifiers
Doi:
10.1371/journal.ppat.1001053
ISSN:
15537366
e-ISSN:
15537374
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Participants Gender
Male