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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
TP53 mutations in squamous-cell carcinomas of the conjunctiva: Evidence for UV-induced mutagenesis
Mutagenesis, Volume 19, No. 5, Year 2004
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Description
Squamous cell carcinoma of the conjunctiva is associated with sun exposure and often occurs in HIV-positive individuals. We have analysed TP53 mutations in 21 cases of squamous cell carcinoma and 22 controls with benign conjunctival lesions from a region (Uganda, Africa) with a high prevalence of heavy sun exposure and HIV infection. TP53 mutations were detected in 11 cases (52%) and 3 controls (14%). Seven of the mutations (6 in cases and 1 in controls) were CC→TT transitions, a molecular signature of mutagenesis by solar UV rays. A similar prevalence (56%) of TP53 mutations was found in 18 squamous cell carcinoma cases positive for epidermodysplasia verruciformis human papillomavirus types. The prevalence of CC→TT transitions reported here is the highest observed in any cancer type and matches that of skin cancers in subjects with xeroderma pigmentosum, an inherited disease with hypersensitivity to UV damage. These results confirm at the molecular level the causal role of solar UV rays in the aetiology of squamous cell carcinoma of the conjunctiva and suggest that infection with epidermodysplasia verruciformis types of human papillomavirus may act as a cofactor to increase the sensitivity of conjunctiva cells to UV-induced mutagenesis. © UK Environmental Mutagen Society 2004; all rights reserved.
Authors & Co-Authors
Ateenyi-Agaba, Charles
Uganda, Kampala
Makerere University
Dai, Min
France, Lyon
Centre International de Recherche Sur le Cancer
Le Calvez, Florence
France, Lyon
Centre International de Recherche Sur le Cancer
Katongole-Mbidde, Edward
Uganda, Kampala
Uganda Cancer Institute
Smet, A.
France, Lyon
Centre International de Recherche Sur le Cancer
Tommasino, Massimo
France, Lyon
Centre International de Recherche Sur le Cancer
Franceschi, Silvia F.
France, Lyon
Centre International de Recherche Sur le Cancer
Hainaut, Pierre L.
France, Lyon
Centre International de Recherche Sur le Cancer
Weiderpass, Elisabete
France, Lyon
Centre International de Recherche Sur le Cancer
Sweden, Stockholm
Karolinska Institutet
Finland, Helsinki
Suomen Syöpärekisteri
Norway, Oslo
Cancer Registry of Norway
Statistics
Citations: 89
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1093/mutage/geh048
ISSN:
02678357
Research Areas
Cancer
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Uganda