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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Submicroscopic infections with Plasmodium falciparum during pregnancy and their association with circulating cytokine, chemokine, and cellular profiles
Clinical and Vaccine Immunology, Volume 21, No. 6, Year 2014
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Description
The immunological consequences of pregnancy-associated malaria (PAM) due to Plasmodium falciparum have been extensively investigated in cross-sectional studies conducted at delivery, but there have been very few longitudinal studies of changes due to PAM during pregnancy. We conducted a prospective study in Benin to investigate the changes associated with PAM in groups of 131 and 111 women at inclusion in the second trimester and at delivery, respectively. Infected women were identified by standard microscopic examinations of blood smears and by quantitative PCR (qPCR) assays and were matched to uninfected control women by age, gestational age, and gravidity. We quantified plasma levels of a panel of soluble immunological mediators and other mediators, as well as the frequencies of peripheral blood mononuclear cell types. Comparisons of these variables in infected and uninfected women used multivariate analyses, and we also assessed the predictive value of variables measured at inclusion for pregnancy outcomes at delivery. In multivariate analyses, peripheral plasma interleukin 10 (IL-10) and gamma interferon-inducible protein 10 (IP-10) levels were associated with PAM at inclusion and at delivery, while higher IL-10 levels distinguished qPCR-detectable submicroscopic infections at inclusion but not at delivery. Maternal anemia at delivery was associated with markers of proinflammatory (increased frequency of monocytes) and anti-inflammatory (increased IL-10 levels and increased activation of regulatory T cells) activity measured at inclusion. Elevated concentrations of IL-10 are associated with the majority of P. falciparum infections during pregnancy, but this marker alone does not identify all submicroscopic infections. Reliably identifying such occult infections will require more sensitive and specific methods. Copyright © 2014 American Society for Microbiology. All Rights Reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4054237/bin/supp_21_6_859__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC4054237/bin/CVI.00009-14_zcd999095002so1.pdf
Authors & Co-Authors
Ibitokou, Samad A.
Benin, Cotonou
University of Abomey-calavi
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
United States, Galveston
University of Texas Medical Branch, School of Medicine
Boström, Stéphanie
Sweden, Stockholm
Institutionen För Molekylär Biovetenskap, Wenner-grens Institut
Brutus, Laurent
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Tuikue-Ndam, Nicaise
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Vianou, Bertin
Benin, Cotonou
University of Abomey-calavi
Agbowaï, Carine
Benin, Cotonou
University of Abomey-calavi
Zin, Martin Amadoudji
Benin, Cotonou
University of Abomey-calavi
Huynh, Bich Tram
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Massougbodji, Achille
Benin, Cotonou
University of Abomey-calavi
Deloron, Philippe
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Troye-Blomberg, Marita
Sweden, Stockholm
Institutionen För Molekylär Biovetenskap, Wenner-grens Institut
Fievét, Nadine
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Luty, A. J.F.
France, Marseille
Ird Institut de Recherche Pour le Developpement
France, Paris
Université Paris Cité
Statistics
Citations: 19
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1128/CVI.00009-14
ISSN:
15566811
e-ISSN:
1556679X
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Benin
Participants Gender
Female