Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Dectin-1 plays a redundant role in the immunomodulatory activities ofβ-glucan-rich ligands in vivo
Microbes and Infection, Volume 15, No. 6-7, Year 2013
Notification
URL copied to clipboard!
Description
β-Glucans are known for their ability to trigger both protective and damaging immune responses. Here we have explored the role of the beta-glucan receptor Dectin-1 in archetypical models of protective and non-protective immunomodulation induced by beta-glucan rich ligands. In the first model, we explored the role of Dectin-1 in the ability of soluble purified β-glucans to mediate protection against systemic Staphylococcus aureus infection in mice. In the second model, we explored the role of Dectin-1 in zymosan induced multiple organ dysfunction syndrome. In both cases, these β-glucan rich compounds had marked effects invivo which were unaltered by Dectin-1 deficiency, suggesting that this receptor has a redundant role in these murine models. © 2013 Institut Pasteur.
Authors & Co-Authors
Marakalala, Mohlopheni Jackson
South Africa, Cape Town
University of Cape Town
Williams, David L.
United States, Johnson
Quillen-dishner College of Medicine
Hoving, Jennifer Claire
South Africa, Cape Town
University of Cape Town
Engstad, Rolf Einar
Norway, Tromso
Biotec Betaglucans as
Netea, Mihai Gheorghe
Netherlands, Nijmegen
Radboud University Medical Center
Brown, Gordon D.A.
South Africa, Cape Town
University of Cape Town
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Statistics
Citations: 66
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1016/j.micinf.2013.03.002
ISSN:
12864579
e-ISSN:
1769714X