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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Retinal vascular calibers associate differentially with cerebral gray matter and white matter atrophy
Alzheimer Disease and Associated Disorders, Volume 27, No. 4, Year 2013
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Description
Cerebral small-vessel disease is thought to contribute to brain atrophy, but it remains unclear whether it affects the gray matter and white matter atrophy differentially. Retinal vessels provide a direct measure to study cerebral small-vessel disease in vivo. In a cohort of 1065 persons (mean age, 67.5 y and 51% women), from the population-based Rotterdam Study, we investigated how retinal vascular calibers relate to brain atrophy and to gray matter and white matter atrophy separately. Retinal arteriolar and venular calibers were semiautomatically measured on digitized fundus transparencies. Using automated quantification of MRI scans, we obtained whole-brain volume and volumes of gray matter and white matter. Both narrower arteriolar and wider venular calibers were associated with smaller brain volume, independent from each other. These associations were primarily driven by smaller white matter volume, whereas no associations were seen for gray matter volume. Adjustments for cardiovascular risk factors attenuated the results, but wider venular caliber remained borderline significantly associated with smaller white matter volume. Our data provide evidence that cerebral small-vessel disease contributes to brain atrophy primarily by affecting the cerebral white matter. Copyright © 2013 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Ikram, Mohammad Kamran
Netherlands, Rotterdam
Erasmus Mc
Netherlands, Groningen
Departments of Ophthalmology
Nigeria, Singapore City
Singapore National Eye Centre
Singapore, Singapore City
Nus Yong Loo Lin School of Medicine
Singapore, Singapore City
National University Health System
De Jong, Frank J.
Netherlands, Rotterdam
Erasmus Mc
Singapore
Departments of Neurology
Vernooij, Meike W.
Netherlands, Rotterdam
Erasmus Mc
Netherlands, Arnhem
Departments of Radiology
Hofman, Albert
Netherlands, Rotterdam
Erasmus Mc
Niessen, Wiro J.
Netherlands, Arnhem
Departments of Radiology
Netherlands, Rotterdam
Erasmus Mc
Netherlands, Delft
Delft University of Technology
van der Lugt, Aad J.
Netherlands, Arnhem
Departments of Radiology
Klaver, Caroline C.W.
Netherlands, Rotterdam
Erasmus Mc
Netherlands, Groningen
Departments of Ophthalmology
Ikram, Mohammad Arfan
Netherlands, Rotterdam
Erasmus Mc
Singapore, Singapore City
National University Health System
Netherlands, Arnhem
Departments of Radiology
Statistics
Citations: 17
Authors: 8
Affiliations: 8
Identifiers
Doi:
10.1097/WAD.0b013e31829344ed
ISSN:
08930341
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Female