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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Maternal toxicity and pregnancy complications in human immunodeficiency virus-infected women receiving antiretroviral therapy: PACTG 316
American Journal of Obstetrics and Gynecology, Volume 190, No. 2, Year 2004
Notification
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Description
Objective: The purpose of this study was to evaluate rates of maternal toxicity, pregnancy complications, and peripartum morbidity by type and duration of antiretroviral therapy (ART) during pregnancy. Study design: The Pediatric AIDS Clinical Trials Group (PACTG) Protocol 316 (PACTG 316) study evaluated the addition of intrapartum/neonatal nevirapine to background ART to reduce perinatal transmission of human immunodeficiency virus-1 (HIV-1). For this secondary analysis, women were categorized into one of six groups on the basis of ART during pregnancy (monotherapy [monoRx], combination without protease inhibitor [PI], combination with PI), and start time (early: before or during first trimester; late: second or third trimester). Results: One thousand four hundred seven women were included: 288 monoRx late, 34 monoRx early, 327 combo, no PI late, 175 combo, no PI early, 320 combo, PI late, and 263 combo, PI early. Symptoms and laboratory abnormalities of moderate grade or more occurred in less than 5% of women. Only gestational diabetes (highest in combo PI early) varied significantly by therapy group. Conclusion: In HIV-infected women receiving prenatal care and ART, adverse events were uncommon. © 2004 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Watts, Diane Heather
United States, Bethesda
National Institute of Child Health and Human Development Nichd
United States, Bethesda
National Institutes of Health Nih
Maupin, Robert T.
United States, New Orleans
Louisiana State University
Fiore, Simona
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Newell, Marie Louise
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Delfraissy, Jean François
Unknown Affiliation
Gelber, Richard D.
United States, Boston
Harvard T.h. Chan School of Public Health
Mofenson, Lynne M.
United States, Bethesda
National Institute of Child Health and Human Development Nichd
Culnane, M.
United States, Atlanta
Centers for Disease Control and Prevention
Cunningham, Coleen K.
United States, Albany
State University of new York System
Statistics
Citations: 89
Authors: 9
Affiliations: 9
Identifiers
Doi:
10.1016/j.ajog.2003.07.018
ISSN:
00029378
Research Areas
Infectious Diseases
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Participants Gender
Female