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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The PRECISE RCT: Evolution of an Early Septic Shock Fluid Resuscitation Trial
Transfusion Medicine Reviews, Volume 26, No. 4, Year 2012
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Description
Severe sepsis and septic shock are the most common reasons for admission to an intensive care unit; and the risk of death is substantial, estimated at approximately 40%. Evidence suggests that early resuscitation strategies that include the use of resuscitation fluids, antibiotics, blood, and inotropes reduce death. Although fluid resuscitation is an immediate life-saving intervention, a fundamental question that remains unanswered is whether the type of resuscitation fluid impacts survival when it is initiated very early in the course of septic shock. A randomized controlled trial published in 2008 confirmed that hydroxyethyl starch fluids cause acute renal failure defined by the requirement for renal replacement therapy. In contrast, a subgroup analysis from a randomized controlled trial suggests that 4% albumin fluid may reduce death from severe sepsis; however, these findings require confirmation in a large randomized trial. Our team is planning a pragmatic early septic shock fluid resuscitation trial that will compare the effectiveness of 5% albumin vs normal saline on 90-day mortality (PRECISE). In this article, we summarize the scientific rationale and inherent challenges associated with the conduct of PRECISE, the background work and planning elements that have been undertaken, and the PRECISE RCT protocol with rationale and justifications provided for the chosen population, the interventions, and the outcome measures. © 2012 Elsevier Inc.
Authors & Co-Authors
McIntyre, Lauralyn A.
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Fergusson, Dean A.
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Rowe, Brian H.
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Cook, Deborah J.
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Arabi, Yaseen M.
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Bagshaw, Sean M.
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Émond, Marcel
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Finfer, Simon R.
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Fox-Robichaud, Alison E.
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Gray, Alasdair James
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Robert S. Green, Robert S.
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Hébert, Paul C.
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Lang, Eddy S.
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Marshall, John C.
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Stiell, Ian G.
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Tinmouth, Alan T.
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Pagliarello, Giuseppe
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Turgeon, Alexis F.
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Walsh, Timothy Simon
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Worster, Andrew S.
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Zarychanski, Ryan
Canada, Ottawa
Ottawa Hospital Research Institute
Canada, Edmonton
University of Alberta
Canada, Hamilton
Mcmaster University
Saudi Arabia, Riyadh
King Abdulaziz Medical City - Riyadh
Canada, Quebec
Chu de Québec-université Laval
Australia, Sydney
George Institute for International Health
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Canada, Halifax
Dalhousie University
Canada, Calgary
University of Calgary
Canada, Toronto
Keenan Research Centre for Biomedical Science
Canada, Ottawa
University of Ottawa
Canada, Winnipeg
University of Manitoba
Statistics
Citations: 21
Authors: 21
Affiliations: 12
Identifiers
Doi:
10.1016/j.tmrv.2011.11.003
ISSN:
08877963
e-ISSN:
15329496
Study Design
Randomised Control Trial
Cross Sectional Study
Study Approach
Quantitative