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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Genetic consequences of mass human chemotherapy for Schistosoma mansoni: Population structure pre-and post-praziquantel treatment in Tanzania
American Journal of Tropical Medicine and Hygiene, Volume 83, No. 4, Year 2010
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Description
Recent shifts in global health policy have led to the implementation of mass drug administration (MDA) for neglected tropical diseases. Here we show how population genetic analyses can provide vital insights into the impact of such MDA on endemic parasite populations. We show that even a single round of MDA produced a genetic bottleneck with reductions in a range of measures of genetic diversity of Schistosoma mansoni. Phylogenetic analyses and indices of population differentiation indicated that schistosomes collected in the same schools in different years were more dissimilar than those from different schools collected within either of the study's 2 years, in addition to distinguishing re-infection from non-clearance (that might indicate putatively resistant parasites) from within those children infected at both baseline and follow-up. Such unique results illustrate the importance of genetic monitoring and examination of long lived multi-cellular parasites such as these under novel or increased chemotherapeutic selective pressures. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Norton, Alice J.
United Kingdom, London
Imperial College London
United Kingdom, London
Wellcome Trust
Gower, Charlotte M.
United Kingdom, London
Imperial College London
Lamberton, Poppy H.L.
United Kingdom, London
Imperial College London
Webster, Bonnie L.
United Kingdom, London
The Natural History Museum, London
Lwambo, Nicholas J.S.
Tanzania, Tanga
National Institute for Medical Research Tanga
Blair, Lynsey
United Kingdom, London
Imperial College London
Fenwick, Alan
United Kingdom, London
Imperial College London
Webster, Joanne P.
United Kingdom, London
Imperial College London
Statistics
Citations: 81
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.4269/ajtmh.2010.10-0283
ISSN:
00029637
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Tanzania