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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Modelling interactions of acid-base balance and respiratory status in the toxicity of metal mixtures in the American oyster Crassostrea virginica
Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology, Volume 155, No. 3, Year 2010
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Description
Heavy metals, such as copper, zinc and cadmium, represent some of the most common and serious pollutants in coastal estuaries. In the present study, we used a combination of linear and artificial neural network (ANN) modelling to detect and explore interactions among low-dose mixtures of these heavy metals and their impacts on fundamental physiological processes in tissues of the Eastern oyster, Crassostrea virginica. Animals were exposed to Cd (0.001-0.400 μM), Zn (0.001-3.059 μM) or Cu (0.002-0.787 μM), either alone or in combination for 1 to 27 days. We measured indicators of acid-base balance (hemolymph pH and total CO2), gas exchange (Po2), immunocompetence (total hemocyte counts, numbers of invasive bacteria), antioxidant status (glutathione, GSH), oxidative damage (lipid peroxidation; LPx), and metal accumulation in the gill and the hepatopancreas. Linear analysis showed that oxidative membrane damage from tissue accumulation of environmental metals was correlated with impaired acid-base balance in oysters. ANN analysis revealed interactions of metals with hemolymph acid-base chemistry in predicting oxidative damage that were not evident from linear analyses. These results highlight the usefulness of machine learning approaches, such as ANNs, for improving our ability to recognize and understand the effects of sub-acute exposure to contaminant mixtures. © 2009 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Macey, Brett M.
United States, Charleston
Hollings Marine Laboratory
United States, Charleston
College of Charleston
South Africa, Cape Town
Marine and Coastal Management
Jenny, Matthew J.
United States, Woods Hole
Woods Hole Oceanographic Institution
Williams, Heidi R.
United States, Charleston
Hollings Marine Laboratory
United States, Charleston
College of Charleston
Thibodeaux, Lindy K.
United States, Charleston
Hollings Marine Laboratory
United States, Charleston
College of Charleston
Beal, Marion
United States, Charleston
Hollings Marine Laboratory
United States, Charleston
South Carolina Marine Resources Research Institute
Almeida, Jonas S.
United States, Charleston
Medical University of South Carolina
Cunningham, Charles
United States, Charleston
Hollings Marine Laboratory
United States, Charleston
Medical University of South Carolina
United States, Albuquerque
The University of new Mexico
Mancia, Annalaura
United States, Charleston
Hollings Marine Laboratory
United States, Charleston
Medical University of South Carolina
Warr, Gregory W.
United States, Charleston
Hollings Marine Laboratory
United States, Charleston
Medical University of South Carolina
United States, Alexandria
National Science Foundation
Burge, Erin J.
United States, Charleston
Hollings Marine Laboratory
United States, Charleston
College of Charleston
United States, Conway
Coastal Carolina University
Holland, A. Fred
United States, Charleston
Hollings Marine Laboratory
Gross, Paul S.
United States, Charleston
Hollings Marine Laboratory
United States, Charleston
Medical University of South Carolina
Hikima, Sonomi
United States, Charleston
Hollings Marine Laboratory
United States, Charleston
Medical University of South Carolina
Burnett, Karen G.
United States, Charleston
Hollings Marine Laboratory
United States, Charleston
College of Charleston
Burnett, Louis
United States, Charleston
Hollings Marine Laboratory
United States, Charleston
College of Charleston
Chapman, Robert W.
United States, Charleston
Hollings Marine Laboratory
United States, Charleston
College of Charleston
United States, Charleston
South Carolina Marine Resources Research Institute
United States, Charleston
Medical University of South Carolina
Statistics
Citations: 16
Authors: 16
Affiliations: 9
Identifiers
Doi:
10.1016/j.cbpa.2009.11.019
ISSN:
10956433
e-ISSN:
15314332