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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
engineering
An impedimetric DNA sensor based on functionalized magnetic nanoparticles for HIV and HBV detection
Sensors and Actuators, B: Chemical, Volume 134, No. 2, Year 2008
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Description
We report a new approach based on DNA hybridization for detecting HBV virus using non-faradic electrochemical impedance spectroscopy. DNA probes modified with biotin in 5′ position were immobilized on streptavidin modified magnetic nanoparticles by biotin-streptavidin interaction. A layer of functionalized nanoparticles was directly immobilized on bare gold electrode using a magnet. Before detection atomic force microscopy was used to visualize the layer of magnetic nanoparticles and cyclic voltammetry permitted to characterize DNA probe immobilization. The hybridization reactions with specific complementary DNA target and no complementary target were investigated by non-faradic impedance spectroscopy. Results show the good immobilization of the DNA probes and the hybridization with different concentrations of complementary DNA. Non-faradic impedance spectroscopy allows to detect 50 pmol of HBV DNA and 160 pmol of HIV DNA on sample of 20 μL. Saturations were reached for the same concentration 12.65 nmol/mL for a same quantity of immobilized DNA probes. © 2008 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Hassen, Walid Mohamed
France, Lyon
Université de Lyon
Chaix, Carole
France, Lyon
Université de Lyon
Abdelghani, Adnane
Tunisia, La Marsa
University of Carthage, Institut Préparatoire Aux Études Scientifiques et Techniques
Bessueille, François
France, Lyon
Université de Lyon
Léonard, Didier
France, Lyon
Université de Lyon
Jaffrézic-Renault, Nicole J.
France, Lyon
Université de Lyon
Statistics
Citations: 106
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.snb.2008.06.020
ISSN:
09254005
Research Areas
Genetics And Genomics
Infectious Diseases