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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Testicular seminoma: 20-year experience at the Northern Israel Oncology Center (1968-1988)
International Urology and Nephrology, Volume 26, No. 4, Year 1994
Notification
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Description
Eighty-four patients with testicular seminoma were treated at the Northern Israel Oncology Center during the years 1968-1988. Using the staging classification of Hussey, 69 patients (82%) had Stage I, eight (10%) had Stage IIA, four (5%) had Stage IIB, one (1%) had Stage IIIA, and two (2%) had Stage IIIB disease. Sixtynine patients (82%) had classic pure seminoma, nine (11%) had anaplastic seminoma and six (7%) had spermatocytic seminoma. Seventy-four patients (88%) underwent high inguinal orchiectomy and ten (12%) had a scrotal approach. Seventy-five patients (85%) were treated with postoperative irradiation. Stage I patients received 26-30 Gy to the paraaortic and ipsilateral pelvic lymph nodes. Stage IIA patients were treated in the same manner with a boost to the involved lymph nodes. With a mean follow-up of 97 months, 65 patients (77%) are alive and well with no evidence of disease, 7 patients (8%) are dead due to disease progression. The 5-, 10-, 15-, and 20-year actuarial survival for all patients was 90%, and for early stage patients 94%. Eight patients (14%) relapsed; 3 of them were salvaged by chemotherapy. Serious side effects of irradiation included lethal respiratory failure due to bleomycin-induced pulmonary fibrosis in one patient, peptic ulcer in three patients, hydronephrosis due to paraureteral fibrosis in one patient and recurrent paralytic ileus in one patient. Eight patients (10%) developed nine second cancers, three of them within the previous radiation field. It is concluded that appropriate planning and adequate radiation dose can yield a 20-year disease-free survival rate for more than 90% of patients with early stage testicular seminoma. Accurate staging may prevent overtreatment, thus reducting long-term toxicity. Because of the risk of developing a second primary cancer, careful follow-up monitoring with a high index of suspicion for such disorders is warranted. © 1994 Akadémiai Kiadó.
Authors & Co-Authors
Stein, Moshe Efraim
Israel, Haifa
Technion - Israel Institute of Technology
Steiner, Mariana
Israel, Haifa
Technion - Israel Institute of Technology
Moshkowitz, B.
Israel, Haifa
Bnai Zion Medical Center
Sapir, D.
Israel, Afula
Emek Medical Center
Kessel, Ivan
South Africa, Johannesburg
Rand Clinic
Kuten, Abraham
Israel, Haifa
Northern Israel Oncology Center
Statistics
Citations: 6
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1007/BF02768019
ISSN:
03011623
e-ISSN:
15732584
Research Areas
Cancer
Health System And Policy
Study Design
Cohort Study