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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
γδ T cells and the immune response in visceral leishmaniasis
European Journal of Immunology, Volume 22, No. 5, Year 1992
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Description
Visceral leishmaniasis (VL) caused by Leishmania donovani, a protozoan parasite, is a disease of high morbidity associated with hepatosplenomegaly, hypergammaglobulinemia, fever and death. One of the immunological hallmarks of VL is a remarkable increase in serum immunoglobulin levels as a result of polyclonal B cell activation. This study demonstrated that T lymphocytes expressing the T cell receptors (TcR) γδ in association with CD3 molecules are increased in circulation of patients with VL. A large proportions of TcR γδ‐bearing T cells had CD4+CD8− phenotype, and expressed CD25, CD38, CD71 and HLA‐DR activation antigens. Furthermore, we demonstrated wide functional differences in TcR γδ and TcR αβ T cells in their proliferative response, secretion of interleukin‐2 (IL‐2), B cell growth factor (BCGF) and B cell differentiation factor (BCDF). It was of interest that the TcR γδ T cells from patients with VL could be expanded by in vitro culture with human recombinant IL‐2. Although these TcR γδ cells secreted diminished levels of IL‐2, they produced highly augmented levels of both BCGF and BCDF, suggesting that secretion of these lymphokines in these T cell subsets is regulated independently. The relative increases in the CD4+ CDw29+ TcR γδ T cell subsets and their secretion of highly elevated levels of BCGF and BCDF largely accounted for the humoral immune system abnormality and hypergammaglobulinemia found in this disease. These observations may help to explain that TcR γδ T cells might be functional in vivo and are involved in immunological mechanisms of pathogenesis in VL. Copyright © 1992 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
Authors & Co-Authors
Raziuddin, Syed
Saudi Arabia, Riyadh
College of Medicine
Telmasani, Abdul Wahab
Saudi Arabia, Riyadh
King Saud University
Saudi Arabia, Abha
Assir Central Hospital
El-Awad, M. E.
Saudi Arabia, Riyadh
King Saud University
Saudi Arabia, Abha
Assir Central Hospital
Al-Amari, Omar M.
Saudi Arabia, Riyadh
College of Medicine
Al-Janadi, Mansour Ahmed
Saudi Arabia, Riyadh
College of Medicine
Statistics
Citations: 69
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1002/eji.1830220506
e-ISSN:
15214141