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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Splenectomy and thrombosis: The case of thalassemia intermedia
Journal of Thrombosis and Haemostasis, Volume 8, No. 10, Year 2010
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Description
Background: Hypercoagulability in splenectomized patients with thalassemia intermedia (TI) has been extensively evaluated. However, clinical and laboratory characteristics of patients who eventually develop overt thromboembolic events (TEE) are poorly studied. Patients/Methods: Three Groups of TI patients (n = 73 each) were retrospectively identified from a registry involving six centers across the Middle East and Italy: Group I, all splenectomized patients with a documented TEE; Group II, age- and sex-matched splenectomized patients without TEE; and Group III, age- and sex-matched nonsplenectomized patients without TEE. Retrieved data included demographics, laboratory parameters, clinical complications, and received treatments that may influence TEE development, and reflected the period prior to TEE occurrence in Group I. Results: The mean age of Group I patients at development of TEE was 33.1 ± 11.7 years, with a male to female ratio of 33:40. TEE were predominantly venous (95%) while four patients (5%) had documented stroke. Among studied parameters, Group I patients weremore likely to have a nucleated red blood cell (NRBC) count ≥ 300 × 106 L-1, a platelet count ≥ 500 × 109 L-1 and evidence of pulmonary hypertension (PHT), or be transfusion nai{dotless}̈ve. The median time to thrombosis following splenectomy was 8 years. Patients with an NRBC count ≥ 300 × 106 L-1, a platelet count ≥ 500 × 109 L-1, or who were transfusion naive also had a shorter time to thrombosis following splenectomy. Conclusion: Splenectomized TI patients who will develop TEE may be identified early on by high NRBC and platelet counts, evidence of PHT, and transfusion naivety. © 2010 International Society on Thrombosis and Haemostasis.
Authors & Co-Authors
Taher, Ali T.
Lebanon, Beirut
American University of Beirut Medical Center
Musallam, Khaled M.
Lebanon, Beirut
American University of Beirut Medical Center
Karimi, Mehran A.
Iran, Shiraz
School of Medicine
El-Beshlawy, Amal M.
Egypt, Cairo
Faculty of Medicine
Belhoul, Khawla M.
United Arab Emirates, Dubai
Al Wasl Hospital
Daar, Shahina F.
Oman, Muscat
Sultan Qaboos University
Saned, Mohamed Salaheldin
United Arab Emirates, Dubai
Al Wasl Hospital
Cesaretti, C.
Italy, Milan
Università Degli Studi Di Milano
Cappellini, Maria Teresa
Italy, Milan
Università Degli Studi Di Milano
Statistics
Citations: 136
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1111/j.1538-7836.2010.03940.x
ISSN:
15387933
e-ISSN:
15387836
Research Areas
Noncommunicable Diseases
Participants Gender
Male
Female