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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Investigation of the antimutagenic effects of selected South African medicinal plant extracts
Toxicology in Vitro, Volume 18, No. 1, Year 2004
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Description
Dichloromethane extracts from different parts of Rhamnus prinoides, Ornithogalum longibracteatum, Gardenia volkensii, Spirostachys africana, Diospyros whyteana, Syzigium cordatum and Prunus africana were investigated for mutagenic and antimutagenic effects in Salmonella/microsome and micronucleus tests. None of the extracts tested in the Ames test were found to induce mutations or to modify the effect of the mutagen 4-nitroquinoline-oxide (4NQO). In the micronucleus test, extracts from twigs/bark of R. prinoides, twigs of D. whyteana, P. africana and S. cordatum significantly lowered the effect of the mutagen mitomycin C (MMC). Extracts from twigs/bark of G. volkensii and S. africana were genotoxic in the micronucleus test, while extracts of O. longibracteatum leaves potentiated the genotoxicity of MMC. This preliminary investigation shows that plant extracts used in traditional medicine may have particular effects with regard to mutagenicity and antimutagenicity indicating careful use in some instances and the need to isolate their active principles for further research. © 2003 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Verschaeve, Luc
Unknown Affiliation
Kestens, V.
Belgium, Mol
Vlaamse Instelling Voor Technologisch Onderzoek
Taylor, Joslyn L.S.
Belgium, Mol
Vlaamse Instelling Voor Technologisch Onderzoek
South Africa, Durban
University of Kwazulu-natal
Elgorashi, Esam E.
Belgium, Mol
Vlaamse Instelling Voor Technologisch Onderzoek
Maes, Annemarie
Belgium, Mol
Vlaamse Instelling Voor Technologisch Onderzoek
van Puyvelde, Luc
Belgium, Ghent
Universiteit Gent
De Kimpe, Norbert G.
Belgium, Ghent
Universiteit Gent
van Staden, Johannes V.
South Africa, Durban
University of Kwazulu-natal
Statistics
Citations: 89
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/S0887-2333(03)00131-0
ISSN:
08872333
Research Areas
Health System And Policy
Infectious Diseases