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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
HIV serological screening in a population of pregnant women in the Republic of Congo: Suitability of different assays
Tropical Medicine and International Health, Volume 13, No. 7, Year 2008
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Description
Different strategies can be applied for the screening of HIV infection, depending on the local seroprevalence. Within a WHO type III strategy, we compared the results of two different second-line methods for HIV screening of a population of pregnant women in the Republic of Congo. Sera from 3614 consecutive pregnant women were tested for HIV with Genescreen Plus Ag/Ab EIA assay; positive specimens were retested with two different second-line methods. (Determine HIV-1/2 rapid test and Vironostika HIV Ag/Ab specific EIA assay). Discordant samples were tested with HIV-1/2 Western Blot and, if necessary, HIV RNA molecular assay. Of the 3614 sera, 221 were positive with Genscreen. Among them, 21 and 10 tested negative with Vironostika and Determine, respectively. A 100% correspondence with 3rd line confirmation test results was found in Genscreen positive/Vironostika negative samples, whereas a 5.5% overestimation of HIV seroprevalence was observed when Determine, instead of Vironostika, was used as second-line test. The choice of appropriate assays in adequate sequence, within the correct WHO strategy, is pivotal to minimize the risk of overtreatment of HIV infection. © 2008 Blackwell Publishing Ltd.
Authors & Co-Authors
Bruzzone, Bianca Marisa
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Bisio, Francesca
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Ventura, Agostina
Italy, Genoa
Università Degli Studi Di Genova
Nigro, Nicola
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Miguel, Landry M.
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Congo, Pointe Noire
Hôpital Régional Des Armées
Mayinda Mboungou, Franc A.
Italy, Genoa
Università Degli Studi Di Genova
Congo, Pointe Noire
Hôpital Régional Des Armées
Nzagou, Abdon C.
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Congo, Pointe Noire
Hôpital Régional Des Armées
Mayembo, Patrice
Congo, Pointe Noire
Hôpital Régional Des Armées
Uberti, Filippo
Italy, Rome
Eni S.p.a., Italy
de Maria, Andrea F.
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Italy, Genoa
Scuola Di Scienze Mediche e Farmaceutiche, Università Degli Studi Di Genova
Icardi, Giancarlo
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Italy, Genoa
Università Degli Studi Di Genova
Viscoli, Claudio
Italy, Genoa
Irccs San Martino Polyclinic Hospital
Statistics
Citations: 12
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1111/j.1365-3156.2008.02090.x
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Congo
Participants Gender
Female