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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Assessment of estrogenic and anti-androgenic activities of the mycotoxin zearalenone and its metabolites using in vitro receptor-specific bioassays
Food and Chemical Toxicology, Volume 74, Year 2014
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Description
Zearalenone (ZEN) is a well-known mycotoxin present in numerous agricultural products. Humans and animals are therefore at a risk of exposure to zearalenone through consumption of contaminated food. After intake, ZEN is reduced to α- and β-zearalenol (α-ZEL and β-ZEL), zearalanone (ZAN), and α- and β-zearalanol (α-ZAL and β-ZAL). Although their estrogenicity has been well characterized, much less is known about their interaction with other nuclear receptors. This study was undertaken to investigate interactions of ZEN and its five metabolites, with the human androgen receptor (hAR) and estrogen receptor alpha (hERα). Their ability to induce hAR-mediated reporter gene expression was examined in androgen-sensitive PALM cells, whereas the effects on hERα function were assessed in MCF-7 cells using the E-Screen bioassay. We confirm that ZEN and its metabolites are full agonists for hERα and demonstrate that all six compounds tested possess hAR-mediated antagonistic activity in PALM cells, in which ZAN, α-ZAL, and β-ZAL were the most effective hAR antagonists. Overall, the observed estrogenic and anti-androgenic potencies of ZEN and its metabolites suggest that these compounds may interfere with the endocrine system by various modes of action and that further investigation is warranted into their role as endocrine disrupters in animals and humans. © 2014 Elsevier Ltd.
Authors & Co-Authors
Molina-Molina, Jose Manuel
Spain, Granada
Universidad de Granada
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Spain, Granada
Instituto de Investigación Biosanitaria de Granada
Real, Macarena
Spain, Granada
Universidad de Granada
Spain, Granada
Instituto de Investigación Biosanitaria de Granada
Jiménez-Díaz, Inmaculada
Spain, Granada
Universidad de Granada
Spain, Granada
Instituto de Investigación Biosanitaria de Granada
Belhassen, Hidaya
Tunisia, Tunis
Université de Tunis el Manar, Centre D'assistance Médicale Urgente Tunis
Hédhili, Abderrazek
Tunisia, Tunis
Université de Tunis el Manar, Centre D'assistance Médicale Urgente Tunis
Torné Poyatos, Pablo
Spain, Granada
Hospital Universitario San Cecilio
Fernández, Mariana Fátima
Spain, Granada
Universidad de Granada
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Spain, Granada
Instituto de Investigación Biosanitaria de Granada
Oleà, Nicolás
Spain, Granada
Universidad de Granada
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Spain, Granada
Instituto de Investigación Biosanitaria de Granada
Statistics
Citations: 73
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1016/j.fct.2014.10.008
ISSN:
02786915
Research Areas
Cancer
Food Security
Genetics And Genomics