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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cefadroxil Compared with Cefaclor in the Treatment of Streptococcal Pneumonia in Adults
Drugs, Volume 32, No. 3, Year 1986
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Description
103 young male Black African gold-miners with pneumococcal pneumonia confirmed by culture or serology were randomly assigned to receive the long acting oral cephalosporin cefadroxil 1g every 12 hours or cefaclor 500mg every 8 hours for 10 days. Clinical cures were obtained in 94% of the group who received cefadroxil and in 94% of the cefaclor group. Similarly, the causative organism S. pneumoniae was eradicated in 98% and 96% of patients who received cefadroxil and cefaclor, respectively. Minimal side effects occurred in both groups, although 1 patient withdrew from therapy with cefaclor because of severe diarrhoea. Thus, cefadroxil and cefaclor both displayed effective antimicrobial activity with low toxicity in the treatment of pneumococcal pneumonia. © 1986, ADIS Press Limited. All rights reserved.
Authors & Co-Authors
ZeLuff, B.
United States, Houston
St. Luke's Episcopal Hospital Houston
Catchpole, M.
South Africa, Carletonville
Leslie Williams Memorial Hospital
Lowe, P.
South Africa, Carletonville
Leslie Williams Memorial Hospital
Koornhof, Hendrik J.
South Africa, Johannesburg
National Health Laboratory Service
Gentry, L.
United States, Houston
St. Luke's Episcopal Hospital Houston
Statistics
Citations: 5
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.2165/00003495-198600323-00008
ISSN:
00126667
Research Areas
Health System And Policy
Infectious Diseases
Participants Gender
Male