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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Ultrasound-induced encapsulated microbubble phenomena
Ultrasound in Medicine and Biology, Volume 30, No. 6, Year 2004
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Description
When encapsulated microbubbles are subjected to high-amplitude ultrasound, the following phenomena have been reported: oscillation, translation, coalescence, fragmentation, sonic cracking and jetting. In this paper, we explain these phenomena, based on theories that were validated for relatively big, free (not encapsulated) gas bubbles. These theories are compared with high-speed optical observations of insonified contrast agent microbubbles. Furthermore, the potential clinical applications of the bubble-ultrasound interaction are explored. We conclude that most of the results obtained are consistent with free gas bubble theory. Similar to cavitation theory, the number of fragments after bubble fission is in agreement with the dominant spherical harmonic oscillation mode. Remarkable are our observations of jetting through contrast agent microbubbles. The pressure at the tip of a jet is high enough to penetrate any human cell. Hence, liquid jets may act as remote-controlled microsyringes, delivering a drug to a region-of-interest. Encapsulated microbubbles have (potential) clinical applications in both diagnostics and therapeutics. © 2004 World Federation for Ultrasound in Medicine & Biology.
Authors & Co-Authors
Postema, Michiel
Netherlands, Rotterdam
Erasmus Mc
Netherlands, Amsterdam
Royal Netherlands Academy of Arts and Sciences - Knaw
Statistics
Citations: 238
Authors: 1
Affiliations: 3
Identifiers
Doi:
10.1016/j.ultrasmedbio.2004.02.010
ISSN:
03015629
Research Areas
Health System And Policy