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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Antibody-dependent eosinophil-mediated damage to
51
CR-labeled schistosomula of Schistosoma Mansoni: Damage by purieid eosinophils*
Journal of Experimental Medicine, Volume 145, No. 1, Year 1977
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Description
After earlier observations that antibody-dependent, cell-mediated damage to 51Cr-labeled schistosomula can be ablated by pretreatment of a mixed preparation of human peripheral blood leukocytes with an anti-eosinophil serum and complement, we investigated the cytotoxic effects of eosinophil-enriched cell preparations. Preparations containing up to 98.5% eosinophils and devoid of neutrophils were effective in mediating antibody-dependent damage to schistosomula. Preparations enriched in mononuclear cells or in neutrophils, and devoid of eosinophils, were inactive. Eosinophfls from some patients with eosinophilia induced by schistosomiasis were less active on a cell-to-cell basis than cells from normal individuals. The possibility that such cells were initially blocked by immune complexes was considered, and it was found that reasonable cytotoxicity by purified eosinophils from patients with eosinophilia could be generated by overnight cultures. A possible requirement for cooperation between eosinophils and other cell types was also studied. Lymphocytes, neutrophfls and monocytes failed to enhance eosinophil-mediated cytotoxicity. These results provide further evidence that the eosinophil is the only cell in man responsible for antibody-dependent, complement-independent damage to schistosomula in vitro. Eosinophils from individuals, however, differ in their cytotoxic potential by a mechanism yet to be elucidated. The possible relationship of these findings to immunity in vivo is discussed. © American Society for Clinical Pathology.
Authors & Co-Authors
Butterworth, Anthony E.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United States, Boston
Harvard Medical School
United States, Cleveland
Case Western Reserve University
Switzerland, Geneva
Organisation Mondiale de la Santé
David, John R.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United States, Boston
Harvard Medical School
United States, Cleveland
Case Western Reserve University
Switzerland, Geneva
Organisation Mondiale de la Santé
Franks, David
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United States, Boston
Harvard Medical School
United States, Cleveland
Case Western Reserve University
Switzerland, Geneva
Organisation Mondiale de la Santé
Mahmoud, Adel A.F.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United States, Boston
Harvard Medical School
United States, Cleveland
Case Western Reserve University
Switzerland, Geneva
Organisation Mondiale de la Santé
David, Peter H.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United States, Boston
Harvard Medical School
United States, Cleveland
Case Western Reserve University
Switzerland, Geneva
Organisation Mondiale de la Santé
Sturrock, Robert F.
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United States, Boston
Harvard Medical School
United States, Cleveland
Case Western Reserve University
Switzerland, Geneva
Organisation Mondiale de la Santé
Houba, Vaclav
Kenya, Nairobi
Wellcome Trust Research Laboratories Nairobi
United States, Boston
Harvard Medical School
United States, Cleveland
Case Western Reserve University
Switzerland, Geneva
Organisation Mondiale de la Santé
Statistics
Citations: 163
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1084/jem.145.1.136
ISSN:
00221007
e-ISSN:
15409538
Research Areas
Infectious Diseases