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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Pharmacological basis for the medicinal use of black pepper and piperine in gastrointestinal disorders
Journal of Medicinal Food, Volume 13, No. 5, Year 2010
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Description
Dried fruits of Piper nigrum (black pepper) are commonly used in gastrointestinal disorders. The aim of this study was to rationalize the medicinal use of pepper and its principal alkaloid, piperine, in constipation and diarrhea using in vitro and in vivo assays. When tested in isolated guinea pig ileum, the crude extract of pepper (Pn.Cr) (1-10 mg/mL) and piperine (3-300 μM) caused a concentration-dependent and atropine-sensitive stimulant effect. In rabbit jejunum, Pn.Cr (0.01-3.0 mg/mL) and piperine (30-1,000 μM) relaxed spontaneous contractions, similar to loperamide and nifedipine. The relaxant effect of Pn.Cr and piperine was partially inhibited in the presence of naloxone (1 μM) similar to that of loperamide, suggesting the naloxone-sensitive effect in addition to the Ca2+ channel blocking (CCB)-like activity, which was evident by its relaxant effect on K+ (80 mM)-induced contractions. The CCB activity was confirmed when pretreatment of the tissue with Pn.Cr (0.03-0.3 mg/mL) or piperine (10-100 μM) caused a rightward shift in the concentration-response curves of Ca2+, similar to loperamide and nifedipine. In mice, Pn.Cr and piperine exhibited a partially atropine-sensitive laxative effect at lower doses, whereas at higher doses it caused antisecretory and antidiarrheal activities that were partially inhibited in mice pretreated with naloxone (1.5 mg/kg), similar to loperamide. This study illustrates the presence of spasmodic (cholinergic) and antispasmodic (opioid agonist and Ca2+ antagonist) effects, thus providing the possible explanation for the medicinal use of pepper and piperine in gastrointestinal motility disorders. © 2010, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition.
Authors & Co-Authors
Mehmood, Malik Hassan
Pakistan, Karachi
The Aga Khan University Medical College
Pakistan, Karachi
University of Karachi
Gilani, Anwar ul Hassan
Pakistan, Karachi
The Aga Khan University Medical College
Saudi Arabia, Riyadh
King Saud University
Statistics
Citations: 81
Authors: 2
Affiliations: 3
Identifiers
Doi:
10.1089/jmf.2010.1065
ISSN:
1096620X
Research Areas
Food Security
Study Locations
Guinea