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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Efficacy and side effects of praziquantel treatment against Schistosoma haematobium infection among primary school children in Zimbabwe
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 102, No. 8, Year 2008
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Description
We examined the efficacy of praziquantel against Schistosoma haematobium among primary school children during a school-based deworming programme in the Burma Valley commercial farming area and the Nyamaropa rural areas in Zimbabwe, where the disease is highly endemic. Among 767 individuals infected with S. haematobium, 675 (88.0%) received treatment. Two single oral doses of 40 mg/kg praziquantel were given 6 weeks apart. Of the 675 participants, heavy infection intensity was more common in males than females (χ2 = 6.61, P = 0.010). Six weeks later, 624 participants (92.4%) were successfully followed up. The overall cure rate was 88.5% and the egg reduction rate was 98.2%. The highest cure rate was among those individuals with light infection. Seventy-two individuals remained infected at 6 weeks post treatment, among which 3 and 69 individuals had heavy and light infection, respectively. Forty-six of these children resolved following a second round of treatment at 6 weeks follow-up. Of the remaining children successfully followed-up, 22 resolved after a third round of treatment 6 months later. A wide range of observed mild and transient side effects were not associated with egg intensity. The parasitological cure rate was not associated with gender or age. Our study demonstrates that praziquantel is efficacious against S. haematobium in Zimbabwe, although low levels of persistent infection warrant further investigation. © 2008.
Authors & Co-Authors
Midzi, Nicholas
Zimbabwe, Harare
National Institute of Health Research, Harare
Sangweme, Davison T.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Zinyowera, Sekesai
Zimbabwe, Harare
College of Health Sciences
Mapingure, Munyaradzi Paul
Zimbabwe, Harare
University of Zimbabwe
Brouwer, Kimberly C.
United States, La Jolla
University of California, San Diego
Kumar, Nirbhay
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Mutapi, Francisca
United Kingdom, Edinburgh
The University of Edinburgh
Woelk, Godfrey B.
Zimbabwe, Harare
University of Zimbabwe
Mduluza, Takafira
Zimbabwe, Harare
University of Zimbabwe
Statistics
Citations: 82
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1016/j.trstmh.2008.03.010
ISSN:
00359203
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Zimbabwe
Participants Gender
Female