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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Tuberculosis may be underestimated in Rwandan women
International Journal of Tuberculosis and Lung Disease, Volume 15, No. 6, Year 2011
Notification
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Description
BACKGROUND AND HYPOTHESIS: The majority of adult tuberculosis (TB) cases reported to the surveillance system in Rwanda are male. If this results from detection mechanisms that are less sensitive to TB in women, notified cases should be more severe in women than in men. METHODS: We analysed the 2006 series of TB cases among persons aged ≥15 years in Huye District and Kigali. Severe TB was defined as disease leading to death, or extra-pulmonary or disseminated TB. RESULTS: Of 1673 cases identified, 40% involved women, who were younger than men (65% vs. 54% aged <35 years). Overall severity was similar in both sexes. Considering age <35 years, women were at higher risk of severe TB than men, although the difference was not statistically significant. Smear-negative pulmonary TB (SNPTB), and human immunodeficiency virus (HIV) infection were more frequent in women than in men (59% vs. 42%, P < 0.001). For women with smear-positive pulmonary TB (SPPTB), the risk of death was twice that among men (adjusted hazard ratio 1.8; 95%CI 1.0-3.2). CONCLUSIONS: Among female TB patients, the higher risk of death with SPPTB, the higher frequency of SNPTB and the higher prevalence of HIV infection suggest that the passive system of case detection may underestimate the burden of TB in Rwandan women. © 2011 The Union.
Authors & Co-Authors
Uwizeye, Claude Bernard
Rwanda, Kigali
Centre for Treatment and Research on Aids
de Serres, Gaston
Canada, Quebec
Université Laval
Canada, Quebec
Institut National de Sante Publique du Québec
Gilca, Rodica
Canada, Quebec
Université Laval
Canada, Quebec
Institut National de Sante Publique du Québec
Schwartzman, Kevin J.
Canada, Montreal
Mcgill Faculty of Medicine and Health Sciences
Gasana, Michel
Rwanda, Kigali
Centre for Treatment and Research on Aids
Statistics
Citations: 13
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.5588/ijtld.10.0454
ISSN:
10273719
Research Areas
Environmental
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Rwanda
Participants Gender
Male
Female