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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Characterization of Melan-A reactive memory CD8+ T cells in a healthy donor
International Immunology, Volume 20, No. 8, Year 2008
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Description
Melan-A specific CD8+ T cells are thought to play an important role against the development of melanoma. Their in vivo expansion is often observed with advanced disease. In recent years, low levels of Melan-A reactive CD8+ T cells have also been found in HLA-A2 healthy donors, but these cells harbor naive characteristics and are thought to be mostly cross-reactive for the Melan-A antigen. Here, we report on a large population of CD8+ T cells reactive for the Melan-A antigen, identified in one donor with no evidence of melanoma. Interestingly, this population is oligoclonal and displays a clear memory phenotype. However, a detailed study of these cells indicated that they are unlikely to be directly specific for melanoma, so that their in vivo expansion may have been driven by an exogenous antigen. Screening of a Melan-A cross-reactive peptide library suggested that these cells may be specific for an epitope derived from a Mycobacterium protein, which would provide a further example of CD8+ T cell cross-reactivity between a pathogen antigen and a tumor antigen. Finally, we discuss potential perspectives regarding the role of such cells in heterologous immunity, by influencing the balance between protective immunity and pathology, e.g. in the case of melanoma development. © The Japanese Society for Immunology. 2008. All rights reserved.
Authors & Co-Authors
Voelter, Verena
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Rufer, Nathalie
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Reynard, Severine
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Greub, Gilbert
Switzerland, Lausanne
Université de Lausanne Unil
Brookes, Roger H.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Guillaume, Philippe
Switzerland, Epalinges
Ludwig Institute for Cancer Research Lausanne
Grosjean, Frederic
Switzerland, Epalinges
Ludwig Institute for Cancer Research Lausanne
Fagerberg, Theres
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Michelin, Olivier
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Rowland-Jones, Sarah Louise
Gambia, Banjul
Medical Research Council Laboratories Gambia
Pinilla, Clemencia
United States, San Diego
Torrey Pines Institute for Molecular Studies
Leyvraz, Serge
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Romero, Pedro J.
Switzerland, Epalinges
Ludwig Institute for Cancer Research Lausanne
Appay, Victor A.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
France, Paris
Inserm
Statistics
Citations: 14
Authors: 14
Affiliations: 7
Identifiers
Doi:
10.1093/intimm/dxn066
ISSN:
09538178
e-ISSN:
14602377
Research Areas
Cancer
Study Design
Cross Sectional Study