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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Evaluation of anti-resistant activity of Auklandia(Saussurea lappa) root against some human pathogens
Asian Pacific Journal of Tropical Biomedicine, Volume 3, No. 7, Year 2013
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Description
Objective: The antimicrobial activity of the ethanol extract of the Auklandia (Saussurea lappa)root plant was investigated to verify its medicinal use in the treatment of microbial infections. Methods: The antimicrobial activity of the ethanol extract was tested against clinical isolates of some multidrug-resistant bacteria using the agar well diffusion method. Commercial antibiotics were used as positive reference standards to determine the sensitivity of the clinical isolates. Results: The extracts showed significant inhibitory activity against clinical isolates of methicillin resistant Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumonia, Extended Spectrum Beta-Lactemase, Acinetobacter baumannii. The minimum inhibitory concentration values obtained using the agar dilution test ranged from 2.0 μg/μL-12.0 μg/μL. In the contrary the water extract showed no activity at all against the tested isolates. Furthermore, the results obtained by examining anti-resistant activity of the plant ethanolic extract showed that at higher concentration of the plant extract (12 μg) all tested bacteria isolates were inhibited with variable inhibition zones similar to those obtained when we applied lower extract concentration using the well diffusion assay. Conclusion: The results demonstrated that the crude ethanolic extract of the Auklandia (Saussurea lappa) root plant has a wide spectrum of activity suggesting that it may be useful in the treatment of infections caused by the above clinical isolates (human pathogens). © 2013 Asian Pacific Tropical Biomedical Magazine.
Authors & Co-Authors
Hasson, Sidgi Syed Anwer
Oman, Muscat
Sultan Qaboos University
Al-Balushi, Mohammed Saeed
Oman, Muscat
Sultan Qaboos University
KhazinaAlharthy,
Oman, Muscat
Sultan Qaboos University
Al-Busaidi, Juma Zaid
Oman, Muscat
Sultan Qaboos University
MunaSulimanAldaihani,
Oman, Muscat
Sultan Qaboos University
Othman, Mohammed Shafeeq
Oman, Muscat
Sultan Qaboos University
Said, Elias Anthony
Oman, Muscat
Sultan Qaboos University
Habal, Omar
Oman, Muscat
Sultan Qaboos University
Sallam, T. A.
Saudi Arabia, Al-baha
Al Baha University
Al-Jabri, Ali Abdullah
Oman, Muscat
Sultan Qaboos University
Idris, M. A.
Oman, Muscat
Sultan Qaboos University
Statistics
Citations: 42
Authors: 11
Affiliations: 2
Identifiers
Doi:
10.1016/S2221-1691(13)60113-6
ISSN:
22211691
Research Areas
Environmental