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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Coinfection of Ugandan red colobus (Procolobus [Piliocolobus] rufomitratus tephrosceles) with novel, divergent delta-, lenti-, and spumaretroviruses
Journal of Virology, Volume 83, No. 21, Year 2009
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Description
Nonhuman primates host a plethora of potentially zoonotic microbes, with simian retroviruses receiving heightened attention due to their roles in the origins of human immunodeficiency viruses type 1 (HIV-1) and HIV-2. However, incomplete taxonomic and geographic sampling of potential hosts, especially the African colobines, has left the full range of primate retrovirus diversity unexplored. Blood samples collected from 31 wild-living red colobus monkeys (Procolobus [Piliocolobus] rufomitratus tephrosceles) from Kibale National Park, Uganda, were tested for antibodies to simian immunodeficiency virus (SIV), simian T-cell lymphotrophic virus (STLV), and simian foamy virus (SFV) and for nucleic acids of these same viruses using genus-specific PCRs. Of 31 red colobus tested, 22.6% were seroreactive to SIV, 6.4% were seroreactive to STLV, and 97% were seroreactive to SFV. Phylogenetic analyses of SIV polymerase (pol), STLV tax and long terminal repeat (LTR), and SFV pol and LTR sequences revealed unique SIV and SFV strains and a novel STLV lineage, each divergent from corresponding retroviral lineages previously described in Western red colobus (Procolobus badius badius) or black-and-white colobus (Colobus guereza). Phylogenetic analyses of host mitochondrial DNA sequences revealed that red colobus populations in East and West Africa diverged from one another approximately 4.25 million years ago. These results indicate that geographic subdivisions within the red colobus taxonomic complex exert a strong influence on retroviral phylogeny and that studying retroviral diversity in closely related primate taxa should be particularly informative for understanding host-virus coevolution. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Goldberg, Tony L.
United States, Madison
University of Wisconsin School of Veterinary Medicine
Uganda, Kampala
Makerere University
Sintasath, David M.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Chapman, Colin A.
Canada, Sainte-anne-de-bellevue
Mcgill University, Macdonald Campus
United States, New York
Wildlife Conservation Society
Uganda, Kampala
Makerere University
Cameron, Kenneth N.
United States, New York
Wildlife Conservation Society
Karesh, William B.
United States, New York
Wildlife Conservation Society
Tang, Shaohua
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Wolfe, Nathan D.
United States, San Francisco
Global Viral Forecasting Initiative
United States, Palo Alto
Stanford University
Rwego, Innocent B.
Uganda, Kampala
Makerere University
Ting, Nelson
United States, Iowa City
University of Iowa
Switzer, William M.
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Statistics
Citations: 63
Authors: 10
Affiliations: 9
Identifiers
Doi:
10.1128/JVI.02616-08
ISSN:
0022538X
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Multi-countries
Uganda